Cargando…

Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease

Dysfunctional dopaminergic neurotransmission is central to movement disorders and mental diseases. The dopamine transporter (DAT) regulates extracellular dopamine levels, but the genetic and mechanistic link between DAT function and dopamine-related pathologies is not clear. Particularly, the pathop...

Descripción completa

Detalles Bibliográficos
Autores principales:	Herborg, Freja, Jensen, Kathrine L., Tolstoy, Sasha, Arends, Natascha V., Posselt, Leonie P., Shekar, Aparna, Aguilar, Jenny I., Lund, Viktor K., Erreger, Kevin, Rickhag, Mattias, Lycas, Matthew D., Lonsdale, Markus N., Rahbek-Clemmensen, Troels, Sørensen, Andreas T., Newman, Amy H., Løkkegaard, Annemette, Kjærulff, Ole, Werge, Thomas, Møller, Lisbeth B., Matthies, Heinrich J.G., Galli, Aurelio, Hjermind, Lena E., Gether, Ulrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492322/ https://www.ncbi.nlm.nih.gov/pubmed/34375312 http://dx.doi.org/10.1172/jci.insight.151496

Ejemplares similares

Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains
por: Rahbek-Clemmensen, Troels, et al.
Publicado: (2017)

A density-based enrichment measure for assessing colocalization in single-molecule localization microscopy data
por: Ejdrup, Aske L., et al.
Publicado: (2022)

Behavioral encoding across timescales by region-specific dopamine dynamics
por: Jørgensen, Søren H., et al.
Publicado: (2023)

Disruption of the PDZ domain–binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation
por: Sørensen, Gunnar, et al.
Publicado: (2021)

Amphetamine-induced reverse transport of dopamine does not require cytosolic Ca(2+)
por: Støier, Jonatan Fullerton, et al.
Publicado: (2023)

PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis
por: Jensen, Kathrine Louise, et al.
Publicado: (2018)

Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity
por: Lycas, Matthew D., et al.
Publicado: (2022)

A C-terminal PDZ domain binding sequence is required for striatal distribution of the dopamine transporter
por: Rickhag, Mattias, et al.
Publicado: (2013)

Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout
por: Giguère, Nicolas, et al.
Publicado: (2019)

Rare Autism-Associated Variants Implicate Syntaxin 1 (STX1 R26Q) Phosphorylation and the Dopamine Transporter (hDAT R51W) in Dopamine Neurotransmission and Behaviors
por: Cartier, Etienne, et al.
Publicado: (2015)

Structural basis of organic cation transporter-3 inhibition
por: Khanppnavar, Basavraj, et al.
Publicado: (2022)

Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors
por: Klein Herenbrink, Carmen, et al.
Publicado: (2022)

Paroxysmal Cranial Dyskinesia and Nail‐Patella Syndrome Caused by a Novel Variant in the LMX1B Gene
por: Bech, Sara, et al.
Publicado: (2020)

Calmodulin kinase II regulates amphetamine-induced reverse transport in dopamine and serotonin transporters
por: Steinkellner, Thomas, et al.
Publicado: (2012)

Within-Mice Comparison of Microdialysis and Fiber Photometry-Recorded Dopamine Biosensor during Amphetamine Response
por: Ejdrup, Aske L., et al.
Publicado: (2023)

PICK1 Deficiency Impairs Secretory Vesicle Biogenesis and Leads to Growth Retardation and Decreased Glucose Tolerance
por: Holst, Birgitte, et al.
Publicado: (2013)

Zn(2+) reverses functional deficits in a de novo dopamine transporter variant associated with autism spectrum disorder
por: Hamilton, Peter J, et al.
Publicado: (2015)

Linking Impulsivity to Activity Levels in Pre-Supplementary Motor Area during Sequential Gambling
por: Lohse, Allan, et al.
Publicado: (2023)

Dissociating reward sensitivity and negative urgency effects on impulsivity in the five-choice serial reaction time task
por: Toschi, Chiara, et al.
Publicado: (2022)

Genome-Wide Association Study of Genetic Variants in LPS-Stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α Cytokine Response in a Danish Cohort
por: Larsen, Margit Hørup, et al.
Publicado: (2013)

Severe and rapidly progressing cognitive phenotype in a SCA17-family with only marginally expanded CAG/CAA repeats in the TATA-box binding protein gene: A case report
por: Nielsen, Troels Tolstrup, et al.
Publicado: (2012)

A clinical classification acknowledging neuropsychiatric and cognitive impairment in Huntington’s disease
por: Vinther-Jensen, Tua, et al.
Publicado: (2014)

It takes two—or more—to tango: Revisiting the role of dopamine transporter oligomerization
por: Gether, Ulrik, et al.
Publicado: (2021)

Deep Brain Stimulation in Parkinson's Disease: Still Effective After More Than 8 Years
por: Thomsen, Birgitte L.C., et al.
Publicado: (2020)

Conformational dynamics of the human serotonin transporter during substrate and drug binding
por: Möller, Ingvar R., et al.
Publicado: (2019)

Linking brain activity during sequential gambling to impulse control in Parkinson's disease
por: Haagensen, Brian N., et al.
Publicado: (2020)

Postprandial Increase in Mesenteric Blood Flow is Attenuated in Parkinson’s Disease: A Dynamic PC-MRI Study
por: Siebner, Thomas Hartwig, et al.
Publicado: (2021)

Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons
por: Runegaard, Annika H., et al.
Publicado: (2018)

Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis
por: Andersen, Rita C., et al.
Publicado: (2022)

Altered sensorimotor activation patterns in idiopathic dystonia—an activation likelihood estimation meta‐analysis of functional brain imaging studies
por: Løkkegaard, Annemette, et al.
Publicado: (2015)

Resting‐state connectivity predicts levodopa‐induced dyskinesias in Parkinson's disease
por: Herz, Damian M., et al.
Publicado: (2016)

Low-frequency transcranial stimulation of pre-supplementary motor area alleviates levodopa-induced dyskinesia in Parkinson’s disease: a randomized cross-over trial
por: Lohse, Allan, et al.
Publicado: (2020)

Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer
por: Jacobsen, Stine Engesgaard, et al.
Publicado: (2017)

The acute brain response to levodopa heralds dyskinesias in Parkinson disease
por: Herz, Damian M., et al.
Publicado: (2014)

Abnormal dopaminergic modulation of striato-cortical networks underlies levodopa-induced dyskinesias in humans
por: Herz, Damian M., et al.
Publicado: (2015)

In Vivo Amphetamine Action is Contingent on αCaMKII
por: Steinkellner, Thomas, et al.
Publicado: (2014)

The Scaffold Protein PICK1 as a Target in Chronic Pain
por: Sørensen, Andreas Toft, et al.
Publicado: (2022)

Differences Between Early and Late Onset Adult Depression
por: Bukh, Jens Drachmann, et al.
Publicado: (2011)

Validity of the diagnosis of a single depressive episode in a case register
por: Bock, Camilla, et al.
Publicado: (2009)

Gastric Emptying Is Not Delayed and Does Not Correlate With Attenuated Postprandial Blood Flow Increase in Medicated Patients With Early Parkinson's Disease
por: Siebner, Thomas Hartwig, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_v7c5khgsgjet9vimdce6eiq3u3