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Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease

Dysfunctional dopaminergic neurotransmission is central to movement disorders and mental diseases. The dopamine transporter (DAT) regulates extracellular dopamine levels, but the genetic and mechanistic link between DAT function and dopamine-related pathologies is not clear. Particularly, the pathop...

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Detalles Bibliográficos
Autores principales:	Herborg, Freja, Jensen, Kathrine L., Tolstoy, Sasha, Arends, Natascha V., Posselt, Leonie P., Shekar, Aparna, Aguilar, Jenny I., Lund, Viktor K., Erreger, Kevin, Rickhag, Mattias, Lycas, Matthew D., Lonsdale, Markus N., Rahbek-Clemmensen, Troels, Sørensen, Andreas T., Newman, Amy H., Løkkegaard, Annemette, Kjærulff, Ole, Werge, Thomas, Møller, Lisbeth B., Matthies, Heinrich J.G., Galli, Aurelio, Hjermind, Lena E., Gether, Ulrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492322/ https://www.ncbi.nlm.nih.gov/pubmed/34375312 http://dx.doi.org/10.1172/jci.insight.151496

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