MLK3 mediates impact of PKG1α on cardiac function and controls blood pressure through separate mechanisms

cGMP-dependent protein kinase 1α (PKG1α) promotes left ventricle (LV) compensation after pressure overload. PKG1-activating drugs improve heart failure (HF) outcomes but are limited by vasodilation-induced hypotension. Signaling molecules that mediate PKG1α cardiac therapeutic effects but do not pro...

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Detalles Bibliográficos
Autores principales: Calamaras, Timothy D., Pande, Suchita, Baumgartner, Robert A.U., Kim, Seung Kyum, McCarthy, Joseph C., Martin, Gregory L., Tam, Kelly, McLaughlin, Angela L., Wang, Guang-rong, Aronovitz, Mark J., Lin, Weiyu, Aguirre, Jonathan I., Baca, Paulina, Liu, Peiwen, Richards, Daniel A., Davis, Roger J., Karas, Richard H., Jaffe, Iris Z., Blanton, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492323/
https://www.ncbi.nlm.nih.gov/pubmed/34324442
http://dx.doi.org/10.1172/jci.insight.149075

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