Cargando…

IFN-γ is essential for alveolar macrophage–driven pulmonary inflammation in macrophage activation syndrome

Macrophage activation syndrome (MAS) is a life-threatening cytokine storm complicating systemic juvenile idiopathic arthritis (SJIA) driven by IFN-γ. SJIA and MAS are also associated with an unexplained emerging inflammatory lung disease (SJIA-LD), with our recent work supporting pulmonary activatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Denny K., Salomonis, Nathan, Henderlight, Maggie, Woods, Christopher, Thakkar, Kairavee, Grom, Alexei A., Thornton, Sherry, Jordan, Michael B., Wikenheiser-Brokamp, Kathryn A., Schulert, Grant S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492332/ https://www.ncbi.nlm.nih.gov/pubmed/34314387 http://dx.doi.org/10.1172/jci.insight.147593

Ejemplares similares

Neutrophils From Children With Systemic Juvenile Idiopathic Arthritis Exhibit Persistent Proinflammatory Activation Despite Long-Standing Clinically Inactive Disease
por: Brown, Rachel A., et al.
Publicado: (2018)

Population-level single-cell genomics reveals conserved gene programs in systemic juvenile idiopathic arthritis
por: Verweyen, Emely L., et al.
Publicado: (2023)

High levels of interferon-gamma (IFNγ) in macrophage activation syndrome (MAS) and CXCL9 levels as a biomarker for IFNγ production in MAS
por: Bracaglia, C, et al.
Publicado: (2015)

Pulmonary alveolar microlithiasis
por: Kosciuk, Patrick, et al.
Publicado: (2020)

Growth Arrest of Alveolar Cells in Response to Cytokines from Spike S1-Activated Macrophages: Role of IFN-γ
por: Barilli, Amelia, et al.
Publicado: (2022)

SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells
por: Huot, Nicolas, et al.
Publicado: (2023)

IFNγ: Issuing macrophages a license to kill
por: Bashyam, Hema
Publicado: (2007)

Differential monocyte microrna expression profiles in children with active systemic juvenile idiopathic arthritis
por: Schulert, Grant, et al.
Publicado: (2014)

Induction of IFN-αβ enables Listeria monocytogenes to suppress macrophage activation by IFN-γ
por: Rayamajhi, Manira, et al.
Publicado: (2010)

Efficacy and safety of emapalumab in macrophage activation syndrome
por: De Benedetti, Fabrizio, et al.
Publicado: (2023)

Functional Regulation of Macrophage Phenotypes by MicroRNAs in Inflammatory Arthritis
por: Niu, Xiaoling, et al.
Publicado: (2019)

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria
por: Rosain, Jérémie, et al.
Publicado: (2023)

Mouse models of systemic juvenile idiopathic arthritis and macrophage activation syndrome
por: Inoue, Natsumi, et al.
Publicado: (2023)

Impaired IFNγ-Signaling and Mycobacterial Clearance in IFNγR1-Deficient Human iPSC-Derived Macrophages
por: Neehus, Anna-Lena, et al.
Publicado: (2017)

The alveolar macrophage.
por: Bowden, D H
Publicado: (1984)

Synergistic Signaling of TLR and IFNα/β Facilitates Escape of IL-18 Expression from Endotoxin Tolerance
por: Verweyen, Emely, et al.
Publicado: (2020)

COVID-19 and cytokine storm syndrome: are there lessons from macrophage activation syndrome?
por: Ombrello, Michael J., et al.
Publicado: (2021)

GSK3α/β restrains IFNγ-inducible costimulatory molecule expression in alveolar macrophages, limiting CD4(+) T cell activation
por: Ankley, Laurisa M., et al.
Publicado: (2023)

Reexamining IFN-γ Stimulation of De Novo NAD+ in Monocyte-Derived Macrophages
por: Moon, Peter, et al.
Publicado: (2018)

Dual oxidase 1 limits the IFNγ-associated antitumor effect of macrophages
por: Meziani, Lydia, et al.
Publicado: (2020)

ILC1-derived IFN-γ regulates macrophage activation in colon cancer
por: Zhang, Yandong, et al.
Publicado: (2023)

SEPTIN2 suppresses an IFN-γ-independent, proinflammatory macrophage activation pathway
por: Fu, Beibei, et al.
Publicado: (2023)

Proceedings from the 2(nd) Next Gen Therapies for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome symposium held on October 3-4, 2019
por: Canna, Scott W., et al.
Publicado: (2020)

Restoration of IFNγR Subunit Assembly, IFNγ Signaling and Parasite Clearance in Leishmania donovani Infected Macrophages: Role of Membrane Cholesterol
por: Sen, Subha, et al.
Publicado: (2011)

A novel STING1 variant causes a recessive form of STING-associated vasculopathy with onset in infancy (SAVI)
por: Lin, Bin, et al.
Publicado: (2020)

Macrophage activation by IFN-γ triggers restriction of phagosomal copper from intracellular pathogens
por: Shen, Qian, et al.
Publicado: (2018)

Correction: Dual oxidase 1 limits the IFNγ-associated antitumor effect of macrophages
Publicado: (2020)

Transcriptome Sequencing Reveals the Antiviral Innate Immunity by IFN-γ in Chinese Sturgeon Macrophages
por: Ding, Guangyi, et al.
Publicado: (2022)

Correction: ILC1-derived IFN-γ regulates macrophage activation in colon cancer
por: Zhang, Yandong, et al.
Publicado: (2023)

Complications of complications: diagnosis and treatment of recurrent macrophage activation syndrome in a patient with well-controlled systemic juvenile idiopathic arthritis
por: Macaraeg, Marci, et al.
Publicado: (2023)

Inflammatory biomarkers in COVID-19-associated multisystem inflammatory syndrome in children, Kawasaki disease, and macrophage activation syndrome: a cohort study
por: Rodriguez-Smith, Jackeline J, et al.
Publicado: (2021)

Alveolar hypoxia, alveolar macrophages, and systemic inflammation
por: Chao, Jie, et al.
Publicado: (2009)

Differential gene expression in LPS/IFNγ activated microglia and macrophages: in vitro versus in vivo
por: Schmid, Christoph D, et al.
Publicado: (2009)

The synergistic interaction between the calcineurin B subunit and IFN-γ enhances macrophage antitumor activity
por: Su, Z, et al.
Publicado: (2015)

Progesterone Alters Kynurenine Pathway Activation in IFN-γ-Activated Macrophages – Relevance for Neuroinflammatory Diseases
por: de Bie, J., et al.
Publicado: (2016)

IFN-γ Stimulates Autophagy-Mediated Clearance of Burkholderia cenocepacia in Human Cystic Fibrosis Macrophages
por: Assani, Kaivon, et al.
Publicado: (2014)

Obesity and Insulin Resistance Promote Atherosclerosis through an IFNγ-Regulated Macrophage Protein Network
por: Reardon, Catherine A., et al.
Publicado: (2018)

C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease
por: Dufour, Antoine, et al.
Publicado: (2018)

The Notch ligand DNER regulates macrophage IFNγ release in chronic obstructive pulmonary disease
por: Ballester-López, Carolina, et al.
Publicado: (2019)

IFN-γ fails to overcome inhibition of selected macrophage activation events in response to pathogenic mycobacteria
por: Thirunavukkarasu, Shyamala, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_gptm8cn68s6lha4t94ren6i6no