Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19

Neutrophils provide a critical line of defense in immune responses to various pathogens, inflicting self-damage upon transition to a hyperactivated, procoagulant state. Recent work has highlighted proinflammatory neutrophil phenotypes contributing to lung injury and acute respiratory distress syndro...

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Detalles Bibliográficos
Autores principales: Kaiser, Rainer, Leunig, Alexander, Pekayvaz, Kami, Popp, Oliver, Joppich, Markus, Polewka, Vivien, Escaig, Raphael, Anjum, Afra, Hoffknecht, Marie-Louise, Gold, Christoph, Brambs, Sophia, Engel, Anouk, Stockhausen, Sven, Knottenberg, Viktoria, Titova, Anna, Haji, Mohamed, Scherer, Clemens, Muenchhoff, Maximilian, Hellmuth, Johannes C., Saar, Kathrin, Schubert, Benjamin, Hilgendorff, Anne, Schulz, Christian, Kääb, Stefan, Zimmer, Ralf, Hübner, Norbert, Massberg, Steffen, Mertins, Philipp, Nicolai, Leo, Stark, Konstantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492337/
https://www.ncbi.nlm.nih.gov/pubmed/34403366
http://dx.doi.org/10.1172/jci.insight.150862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492337/
https://www.ncbi.nlm.nih.gov/pubmed/34403366
http://dx.doi.org/10.1172/jci.insight.150862

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