Mutations in EPHB4 cause human venous valve aplasia

Venous valve (VV) failure causes chronic venous insufficiency, but the molecular regulation of valve development is poorly understood. A primary lymphatic anomaly, caused by mutations in the receptor tyrosine kinase EPHB4, was recently described, with these patients also presenting with venous insuf...

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Detalles Bibliográficos
Autores principales: Lyons, Oliver, Walker, James, Seet, Christopher, Ikram, Mohammed, Kuchta, Adam, Arnold, Andrew, Hernández-Vásquez, Magda, Frye, Maike, Vizcay-Barrena, Gema, Fleck, Roland A., Patel, Ashish S., Padayachee, Soundrie, Mortimer, Peter, Jeffery, Steve, Berland, Siren, Mansour, Sahar, Ostergaard, Pia, Makinen, Taija, Modarai, Bijan, Saha, Prakash, Smith, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492339/
https://www.ncbi.nlm.nih.gov/pubmed/34403370
http://dx.doi.org/10.1172/jci.insight.140952

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