Replenishment of TCA cycle intermediates provides photoreceptor resilience against neurodegeneration during progression of retinitis pigmentosa

The metabolic environment is important for neuronal cells, such as photoreceptors. When photoreceptors undergo degeneration, as occurs during retinitis pigmentosa (RP), patients have progressive loss of vision that proceeds to full blindness. Currently, there are no available treatments for the majo...

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Detalles Bibliográficos
Autores principales: Rowe, Ashley A., Patel, Pinkal D., Gordillo, Ruth, Wert, Katherine J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492344/
https://www.ncbi.nlm.nih.gov/pubmed/34292885
http://dx.doi.org/10.1172/jci.insight.150898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492344/
https://www.ncbi.nlm.nih.gov/pubmed/34292885
http://dx.doi.org/10.1172/jci.insight.150898

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