Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis

Development of primary liver cancer is a multistage process. Detailed understanding of sequential epigenetic alterations is largely missing. Here, we performed Infinium Human Methylation 450k BeadChips and RNA-Seq analyses for genome-wide methylome and transcriptome profiling of cirrhotic liver (n =...

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Detalles Bibliográficos
Autores principales: Czauderna, Carolin, Poplawski, Alicia, O’Rourke, Colm J., Castven, Darko, Pérez-Aguilar, Benjamín, Becker, Diana, Heilmann-Heimbach, Stephanie, Odenthal, Margarete, Amer, Wafa, Schmiel, Marcel, Drebber, Uta, Binder, Harald, Ridder, Dirk A., Schindeldecker, Mario, Straub, Beate K., Galle, Peter R., Andersen, Jesper B., Thorgeirsson, Snorri S., Park, Young Nyun, Marquardt, Jens U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492348/
https://www.ncbi.nlm.nih.gov/pubmed/34375307
http://dx.doi.org/10.1172/jci.insight.146196

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