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Liver function as a predictor of mortality in COVID-19: A retrospective study
INTRODUCTION AND OBJECTIVES: In many studies, varying degrees of liver damage have been reported in more than half of the COVID-19 patients. The aim of this study is to determine the effect of liver biochemical parameters abnormality on mortality in critical COVID-19 patients who have been followed...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Fundación Clínica Médica Sur, A.C. Published by Elsevier España, S.L.U.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492360/ https://www.ncbi.nlm.nih.gov/pubmed/34624543 http://dx.doi.org/10.1016/j.aohep.2021.100553 |
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author | Salık, Fikret Uzundere, Osman Bıçak, Mustafa Akelma, Hakan Akgündüz, Mesut Korhan, Zeki Kandemir, Deniz Kaçar, Cem Kıvılcım |
author_facet | Salık, Fikret Uzundere, Osman Bıçak, Mustafa Akelma, Hakan Akgündüz, Mesut Korhan, Zeki Kandemir, Deniz Kaçar, Cem Kıvılcım |
author_sort | Salık, Fikret |
collection | PubMed |
description | INTRODUCTION AND OBJECTIVES: In many studies, varying degrees of liver damage have been reported in more than half of the COVID-19 patients. The aim of this study is to determine the effect of liver biochemical parameters abnormality on mortality in critical COVID-19 patients who have been followed in the ICU since the beginning of the pandemic process. MATERIALS AND METHODS: In this study 533 critical patients who admitted to the ICU due to COVID-19 were included. The patients were divided into three groups according to their ALT, AST, and total bilirubin levels at their admission to the ICU. Group 1 was formed of patients with normal liver biochemical parameters values; Group 2 was formed of patients with liver biochemical parameters abnormality; Group 3 was formed of patients with liver injury. RESULTS: 353 (66.2%) of all patients died. Neutrophil, aPTT, CRP, LDH, CK, ALT, AST, bilirubin, procalcitonin and ferritin values in Group 2 and Group 3 were found to be statistically significantly higher than Group 1. It was detected that the days of stay in ICU of the patients in Group 1 was statistically significantly longer than others group. It was found that the patients in Groups 2 and 3 had higher total, 7-day, and 28-day mortality rates than expected. CONCLUSIONS: The study showed that liver disfunction was associated with higher mortality and shorter ICU occupation time. |
format | Online Article Text |
id | pubmed-8492360 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Fundación Clínica Médica Sur, A.C. Published by Elsevier España, S.L.U. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84923602021-10-06 Liver function as a predictor of mortality in COVID-19: A retrospective study Salık, Fikret Uzundere, Osman Bıçak, Mustafa Akelma, Hakan Akgündüz, Mesut Korhan, Zeki Kandemir, Deniz Kaçar, Cem Kıvılcım Ann Hepatol Original Article INTRODUCTION AND OBJECTIVES: In many studies, varying degrees of liver damage have been reported in more than half of the COVID-19 patients. The aim of this study is to determine the effect of liver biochemical parameters abnormality on mortality in critical COVID-19 patients who have been followed in the ICU since the beginning of the pandemic process. MATERIALS AND METHODS: In this study 533 critical patients who admitted to the ICU due to COVID-19 were included. The patients were divided into three groups according to their ALT, AST, and total bilirubin levels at their admission to the ICU. Group 1 was formed of patients with normal liver biochemical parameters values; Group 2 was formed of patients with liver biochemical parameters abnormality; Group 3 was formed of patients with liver injury. RESULTS: 353 (66.2%) of all patients died. Neutrophil, aPTT, CRP, LDH, CK, ALT, AST, bilirubin, procalcitonin and ferritin values in Group 2 and Group 3 were found to be statistically significantly higher than Group 1. It was detected that the days of stay in ICU of the patients in Group 1 was statistically significantly longer than others group. It was found that the patients in Groups 2 and 3 had higher total, 7-day, and 28-day mortality rates than expected. CONCLUSIONS: The study showed that liver disfunction was associated with higher mortality and shorter ICU occupation time. Fundación Clínica Médica Sur, A.C. Published by Elsevier España, S.L.U. 2021-12 2021-10-06 /pmc/articles/PMC8492360/ /pubmed/34624543 http://dx.doi.org/10.1016/j.aohep.2021.100553 Text en © 2021 Fundación Clínica Médica Sur, A.C. Published by Elsevier España, S.L.U. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Article Salık, Fikret Uzundere, Osman Bıçak, Mustafa Akelma, Hakan Akgündüz, Mesut Korhan, Zeki Kandemir, Deniz Kaçar, Cem Kıvılcım Liver function as a predictor of mortality in COVID-19: A retrospective study |
title | Liver function as a predictor of mortality in COVID-19: A retrospective study |
title_full | Liver function as a predictor of mortality in COVID-19: A retrospective study |
title_fullStr | Liver function as a predictor of mortality in COVID-19: A retrospective study |
title_full_unstemmed | Liver function as a predictor of mortality in COVID-19: A retrospective study |
title_short | Liver function as a predictor of mortality in COVID-19: A retrospective study |
title_sort | liver function as a predictor of mortality in covid-19: a retrospective study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492360/ https://www.ncbi.nlm.nih.gov/pubmed/34624543 http://dx.doi.org/10.1016/j.aohep.2021.100553 |
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