A Case of Lansoprazole-Induced Bullous Pemphigoid After Zantac Recall

Proton pump inhibitors (PPIs) are the mainstay of treatment for many gastric acid-related diseases with a relatively safe drug profile. One of the rare side effects is PPI-induced bullous pemphigoid. We describe a case of new-onset bullous pemphigoid on initiation of lansoprazole for esophagitis aft...

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Detalles Bibliográficos
Autores principales: Tran, Minh, Armenta, Andrew M., Wilkerson, Michael G., Afrouzian, Marjan, Khan, Kashif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492368/
https://www.ncbi.nlm.nih.gov/pubmed/34621909
http://dx.doi.org/10.14309/crj.0000000000000664
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author Tran, Minh
Armenta, Andrew M.
Wilkerson, Michael G.
Afrouzian, Marjan
Khan, Kashif
author_facet Tran, Minh
Armenta, Andrew M.
Wilkerson, Michael G.
Afrouzian, Marjan
Khan, Kashif
author_sort Tran, Minh
collection PubMed
description Proton pump inhibitors (PPIs) are the mainstay of treatment for many gastric acid-related diseases with a relatively safe drug profile. One of the rare side effects is PPI-induced bullous pemphigoid. We describe a case of new-onset bullous pemphigoid on initiation of lansoprazole for esophagitis after a nationwide Zantac recall. This condition can improve with the cessation of PPI and the use of corticosteroids. However, it poses a significant challenge to the management of gastroesophageal reflux disease by limiting available pharmacologic options. In addition, this case highlights the negative effects of a drug recall.
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spelling pubmed-84923682021-10-06 A Case of Lansoprazole-Induced Bullous Pemphigoid After Zantac Recall Tran, Minh Armenta, Andrew M. Wilkerson, Michael G. Afrouzian, Marjan Khan, Kashif ACG Case Rep J Case Report Proton pump inhibitors (PPIs) are the mainstay of treatment for many gastric acid-related diseases with a relatively safe drug profile. One of the rare side effects is PPI-induced bullous pemphigoid. We describe a case of new-onset bullous pemphigoid on initiation of lansoprazole for esophagitis after a nationwide Zantac recall. This condition can improve with the cessation of PPI and the use of corticosteroids. However, it poses a significant challenge to the management of gastroesophageal reflux disease by limiting available pharmacologic options. In addition, this case highlights the negative effects of a drug recall. Wolters Kluwer 2021-10-04 /pmc/articles/PMC8492368/ /pubmed/34621909 http://dx.doi.org/10.14309/crj.0000000000000664 Text en © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Tran, Minh
Armenta, Andrew M.
Wilkerson, Michael G.
Afrouzian, Marjan
Khan, Kashif
A Case of Lansoprazole-Induced Bullous Pemphigoid After Zantac Recall
title A Case of Lansoprazole-Induced Bullous Pemphigoid After Zantac Recall
title_full A Case of Lansoprazole-Induced Bullous Pemphigoid After Zantac Recall
title_fullStr A Case of Lansoprazole-Induced Bullous Pemphigoid After Zantac Recall
title_full_unstemmed A Case of Lansoprazole-Induced Bullous Pemphigoid After Zantac Recall
title_short A Case of Lansoprazole-Induced Bullous Pemphigoid After Zantac Recall
title_sort case of lansoprazole-induced bullous pemphigoid after zantac recall
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492368/
https://www.ncbi.nlm.nih.gov/pubmed/34621909
http://dx.doi.org/10.14309/crj.0000000000000664
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