Seroprevalence of SARS-CoV-2 immunoglobulins in pregnant women and neonatal cord blood from a highly impacted region

There is inadequate screening for SARS-COV-2 during pregnancy. We aimed to determine the impact of maternal and neonatal cord blood SARS-COV-2 antibodies and placental transfer ratios in a region with a low screening plan. We performed a blind study in one of the SARS-CoV-2 epicenters in South Ameri...

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Autores principales: Zambrano, Hector, Anchundia, Ketty, Aviles, Dalila, Andaluz, Ruffo, Calderon, Nathaly, Torres, Estefanie, Gonzalez-Granda, Nicolas, Maxwell, Anthony, Chen, Kang, Gonik, Bernard, Mor, Gil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492380/
https://www.ncbi.nlm.nih.gov/pubmed/34626893
http://dx.doi.org/10.1016/j.placenta.2021.10.001
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author Zambrano, Hector
Anchundia, Ketty
Aviles, Dalila
Andaluz, Ruffo
Calderon, Nathaly
Torres, Estefanie
Gonzalez-Granda, Nicolas
Maxwell, Anthony
Chen, Kang
Gonik, Bernard
Mor, Gil
author_facet Zambrano, Hector
Anchundia, Ketty
Aviles, Dalila
Andaluz, Ruffo
Calderon, Nathaly
Torres, Estefanie
Gonzalez-Granda, Nicolas
Maxwell, Anthony
Chen, Kang
Gonik, Bernard
Mor, Gil
author_sort Zambrano, Hector
collection PubMed
description There is inadequate screening for SARS-COV-2 during pregnancy. We aimed to determine the impact of maternal and neonatal cord blood SARS-COV-2 antibodies and placental transfer ratios in a region with a low screening plan. We performed a blind study in one of the SARS-CoV-2 epicenters in South America. 32% of pregnant women were serological positive. Importantly, there is an efficient passive immunization of the fetus to SARS-CoV-2. We report high incidence of SARS-CoV-2 infection during pregnancy, which is higher than officially reported. Therefore the need of active immunization to enhance maternal protection and fetal passive immunization.
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spelling pubmed-84923802021-10-06 Seroprevalence of SARS-CoV-2 immunoglobulins in pregnant women and neonatal cord blood from a highly impacted region Zambrano, Hector Anchundia, Ketty Aviles, Dalila Andaluz, Ruffo Calderon, Nathaly Torres, Estefanie Gonzalez-Granda, Nicolas Maxwell, Anthony Chen, Kang Gonik, Bernard Mor, Gil Placenta Short Communication There is inadequate screening for SARS-COV-2 during pregnancy. We aimed to determine the impact of maternal and neonatal cord blood SARS-COV-2 antibodies and placental transfer ratios in a region with a low screening plan. We performed a blind study in one of the SARS-CoV-2 epicenters in South America. 32% of pregnant women were serological positive. Importantly, there is an efficient passive immunization of the fetus to SARS-CoV-2. We report high incidence of SARS-CoV-2 infection during pregnancy, which is higher than officially reported. Therefore the need of active immunization to enhance maternal protection and fetal passive immunization. Elsevier Ltd. 2021-11 2021-10-06 /pmc/articles/PMC8492380/ /pubmed/34626893 http://dx.doi.org/10.1016/j.placenta.2021.10.001 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Zambrano, Hector
Anchundia, Ketty
Aviles, Dalila
Andaluz, Ruffo
Calderon, Nathaly
Torres, Estefanie
Gonzalez-Granda, Nicolas
Maxwell, Anthony
Chen, Kang
Gonik, Bernard
Mor, Gil
Seroprevalence of SARS-CoV-2 immunoglobulins in pregnant women and neonatal cord blood from a highly impacted region
title Seroprevalence of SARS-CoV-2 immunoglobulins in pregnant women and neonatal cord blood from a highly impacted region
title_full Seroprevalence of SARS-CoV-2 immunoglobulins in pregnant women and neonatal cord blood from a highly impacted region
title_fullStr Seroprevalence of SARS-CoV-2 immunoglobulins in pregnant women and neonatal cord blood from a highly impacted region
title_full_unstemmed Seroprevalence of SARS-CoV-2 immunoglobulins in pregnant women and neonatal cord blood from a highly impacted region
title_short Seroprevalence of SARS-CoV-2 immunoglobulins in pregnant women and neonatal cord blood from a highly impacted region
title_sort seroprevalence of sars-cov-2 immunoglobulins in pregnant women and neonatal cord blood from a highly impacted region
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492380/
https://www.ncbi.nlm.nih.gov/pubmed/34626893
http://dx.doi.org/10.1016/j.placenta.2021.10.001
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