Cargando…

The possibility of low isomerization of β-lapachone in the human body

β-Lapachone has been reported to have anticancer and various other therapeutic effects, but is limited in clinical applications by its low bioavailability. pH-Dependent isomerization can be suggested as one plausible factor influencing its low bioavailability. Since it is known that β-lapachone is c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Kyung Min, Gwon, Mi-Ri, Lee, Hae Won, Seong, Sook Jin, Yoon, Young-Ran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Clinical Pharmacology and Therapeutics 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492396/ https://www.ncbi.nlm.nih.gov/pubmed/34621708 http://dx.doi.org/10.12793/tcp.2021.29.e16

Ejemplares similares

Anticancer Potential of Resveratrol, β-Lapachone and Their Analogues
por: Ferraz da Costa, Danielly C., et al.
Publicado: (2020)

Enhancement of radiation effect using beta-lapachone and underlying mechanism
por: Ahn, Ki Jung, et al.
Publicado: (2013)

Pharmacokinetics and Pharmacodynamics of YYD601, a Dual Delayed-Release Formulation of Esomeprazole, Following Single and Multiple Doses in Healthy Adult Volunteers Under Fasting and Fed Conditions
por: Lee, Hae Won, et al.
Publicado: (2022)

β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia
por: Lee, Eun-Jung, et al.
Publicado: (2015)

Pharmacokinetic and safety evaluation of MB12066, an NQO1 substrate
por: Lee, Hae Won, et al.
Publicado: (2017)

Pharmacokinetic Drug Interaction Between Raloxifene and Cholecalciferol in Healthy Volunteers
por: Lee, Hae Won, et al.
Publicado: (2022)

β-Lapachone suppresses the lung metastasis of melanoma via the MAPK signaling pathway
por: Kee, Ji-Ye, et al.
Publicado: (2017)

β-Lapachone Significantly Increases the Effect of Ionizing Radiation to Cause Mitochondrial Apoptosis via JNK Activation in Cancer Cells
por: Park, Moon-Taek, et al.
Publicado: (2011)

β-Lapachone Ameliorates Lipotoxic Cardiomyopathy in Acyl CoA Synthase Transgenic Mice
por: Jeong, Moon Hee, et al.
Publicado: (2014)

A Pharmacokinetic Drug Interaction Between Fimasartan and Linagliptin in Healthy Volunteers
por: Kang, Woo Youl, et al.
Publicado: (2020)

Metabolomic analysis of healthy human urine following administration of glimepiride using a liquid chromatography-tandem mass spectrometry
por: Do, Eun Young, et al.
Publicado: (2017)

Antibacterial and Antibiofilm Activities of β-Lapachone by Modulating the Catalase Enzyme
por: Mir, Mushtaq Ahmad, et al.
Publicado: (2023)

In vitro effects of lapachol and β-lapachone against Leishmania amazonensis
por: Ramos-Milaré, Á.C.F.H., et al.
Publicado: (2023)

Evaluation of the Pharmacokinetic Drug–Drug Interaction between Micronized Fenofibrate and Pitavastatin in Healthy Volunteers
por: Lee, Hae Won, et al.
Publicado: (2020)

Determination of sumatriptan in human plasma using liquid chromatography-mass spectrometry for pharmacokinetic study in healthy Korean volunteers
por: Cho, Seungil, et al.
Publicado: (2017)

A randomized, open-label, single-dose, two-way crossover study to assess the pharmacokinetics between two tablets of fixed-dose combination formulation with raloxifene and cholecalciferol and concomitant administration of each agents in healthy male volunteers
por: Lee, Hae Won, et al.
Publicado: (2022)

Beta-Lapachone, a Modulator of NAD Metabolism, Prevents Health Declines in Aged Mice
por: Lee, Jeong-sook, et al.
Publicado: (2012)

Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor
por: Rodrigues, Tiago, et al.
Publicado: (2018)

Characterization and trypanocidal activity of a β-lapachone-containing drug carrier
por: Barbosa, Juliana M. C., et al.
Publicado: (2021)

Mechanically Robust Gastroretentive Drug-Delivery Systems Capable of Controlling Dissolution Behaviors of Coground β-Lapachone
por: Kim, Hyeongmin, et al.
Publicado: (2019)

Pharmacokinetic and bioequivalence study between two formulations of S-1 in Korean gastric cancer patients
por: Lee, Hae Won, et al.
Publicado: (2019)

Pharmacokinetics and bioequivalence of fixed-dose combination of candesartan cilexetil/amlodipine besylate (16/10 mg) versus coadministration of individual formulations in healthy subjects
por: Lee, Hae Won, et al.
Publicado: (2020)

β-Lapachone ameliorates L-DOPA-induced dyskinesia in a 6-OHDA-induced mouse model of Parkinson's disease
por: Ryu, Young-Kyoung, et al.
Publicado: (2021)

Preclinical Pharmacokinetic Evaluation of β-Lapachone: Characteristics of Oral Bioavailability and First-Pass Metabolism in Rats
por: Kim, Iksoo, et al.
Publicado: (2015)

Population pharmacokinetic and pharmacodynamic modeling of transformed binary effect data of triflusal in healthy Korean male volunteers: a randomized, open-label, multiple dose, crossover study
por: Park, Sung Min, et al.
Publicado: (2014)

Temperature-Sensitive Gels for Intratumoral Delivery of β-Lapachone: Effect of Cyclodextrins and Ethanol
por: Cunha-Filho, Marcilio S. S., et al.
Publicado: (2012)

β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response
por: de B. Oliveira, Ana L., et al.
Publicado: (2020)

Synergistic Effect of β-Lapachone and Aminooxyacetic Acid on Central Metabolism in Breast Cancer
por: Chang, Mario C., et al.
Publicado: (2022)

Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats
por: Jang, Soung Baek, et al.
Publicado: (2013)

Pharmacokinetic and bioequivalence study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828) formulation and coadministered telmisartan and S-amlodipine in healthy subjects
por: Kang, Woo Youl, et al.
Publicado: (2018)

Prenatal diagnosis of atrial isomerism in the Korean population
por: Lee, Mi-Young, et al.
Publicado: (2014)

Pharmacokinetic and bioequivalence study comparing a fimasartan/rosuvastatin fixed-dose combination with the concomitant administration of fimasartan and rosuvastatin in healthy subjects
por: Kang, Woo Youl, et al.
Publicado: (2018)

β-Lapachone Inhibits Lung Metastasis of Colorectal Cancer by Inducing Apoptosis of CT26 Cells
por: Kee, Ji-Ye, et al.
Publicado: (2016)

The Tumor-Selective Cytotoxic Agent β-Lapachone is a Potent Inhibitor of IDO1
por: Flick, Hollie E., et al.
Publicado: (2013)

ANTHELMINTIC ACTIVITY OF LAPACHOL, β-LAPACHONE AND ITS DERIVATIVES AGAINST Toxocara canis LARVAE
por: MATA-SANTOS, Taís, et al.
Publicado: (2015)

Terpinen-4-ol, tyrosol, and β-lapachone as potential antifungals against dimorphic fungi
por: Brilhante, Raimunda Sâmia Nogueira, et al.
Publicado: (2016)

Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone
por: Torrente, Laura, et al.
Publicado: (2020)

Fed and fasted bioequivalence assessment of two formulations of extended-release fixed-dose combination dapagliflozin/metformin (10/1,000 mg) tablets in healthy subjects
por: Lee, Hae Won, et al.
Publicado: (2023)

β-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryos
por: Wu, Yi-Ting, et al.
Publicado: (2011)

NQO1 is Required for β-Lapachone-Mediated Downregulation of Breast-Cancer Stem-Cell Activity
por: Kim, Dong Wook, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_r2jm31nsk8q5u2iat97ucbnid3