Itraconazole Exerts Its Antitumor Effect in Esophageal Cancer By Suppressing the HER2/AKT Signaling Pathway

Itraconazole, an FDA-approved antifungal, has antitumor activity against a variety of cancers. We sought to determine the effects of itraconazole on esophageal cancer and elucidate its mechanism of action. Itraconazole inhibited cell proliferation and induced G(1)-phase cell-cycle arrest in esophage...

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Detalles Bibliográficos
Autores principales: Zhang, Wei, Bhagwath, Ankur S., Ramzan, Zeeshan, Williams, Taylor A., Subramaniyan, Indhumathy, Edpuganti, Vindhya, Kallem, Raja Reddy, Dunbar, Kerry B., Ding, Peiguo, Gong, Ke, Geurkink, Samuel A., Beg, Muhammad S., Kim, James, Zhang, Qiuyang, Habib, Amyn A., Choi, Sung-Hee, Lapsiwala, Ritu, Bhagwath, Gayathri, Dowell, Jonathan E., Melton, Shelby D., Jie, Chunfa, Putnam, William C., Pham, Thai H., Wang, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492513/
https://www.ncbi.nlm.nih.gov/pubmed/34376577
http://dx.doi.org/10.1158/1535-7163.MCT-20-0638

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