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Feasibility of quantitative susceptibility mapping (QSM) of the human kidney
OBJECTIVE: To evaluate the feasibility of in-vivo quantitative susceptibility mapping (QSM) of the human kidney. METHODS: An axial single-breath-hold 3D multi-echo sequence (acquisition time 33 s) was completed on a 3 T-MRI-scanner (Magnetom Prisma, Siemens Healthineers, Erlangen, Germany) in 19 hea...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492554/ https://www.ncbi.nlm.nih.gov/pubmed/33230656 http://dx.doi.org/10.1007/s10334-020-00895-9 |
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author | Bechler, Eric Stabinska, Julia Thiel, Thomas Jasse, Jonas Zukovs, Romans Valentin, Birte Wittsack, Hans-Jörg Ljimani, Alexandra |
author_facet | Bechler, Eric Stabinska, Julia Thiel, Thomas Jasse, Jonas Zukovs, Romans Valentin, Birte Wittsack, Hans-Jörg Ljimani, Alexandra |
author_sort | Bechler, Eric |
collection | PubMed |
description | OBJECTIVE: To evaluate the feasibility of in-vivo quantitative susceptibility mapping (QSM) of the human kidney. METHODS: An axial single-breath-hold 3D multi-echo sequence (acquisition time 33 s) was completed on a 3 T-MRI-scanner (Magnetom Prisma, Siemens Healthineers, Erlangen, Germany) in 19 healthy volunteers. Graph-cut-based unwrapping combined with the T(2)*-IDEAL approach was performed to remove the chemical shift of fat and to quantify QSM of the upper abdomen. Mean susceptibility values of the entire, renal cortex and medulla in both kidneys and the liver were determined and compared. Five subjects were measured twice to examine the reproducibility. One patient with severe renal fibrosis was included in the study to evaluate the potential clinical relevance of QSM. RESULTS: QSM was successful in 17 volunteers and the patient with renal fibrosis. Anatomical structures in the abdomen were clearly distinguishable by QSM and the susceptibility values obtained in the liver were comparable to those found in the literature. The results showed a good reproducibility. Besides, the mean renal QSM values obtained in healthy volunteers (0.04 ± 0.07 ppm for the right and − 0.06 ± 0.19 ppm for the left kidney) were substantially higher than that measured in the investigated fibrotic kidney (− 0.43 ± − 0.02 ppm). CONCLUSION: QSM of the human kidney could be a promising approach for the assessment of information about microscopic renal tissue structure. Therefore, it might further improve functional renal MR imaging. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10334-020-00895-9) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-8492554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-84925542021-10-27 Feasibility of quantitative susceptibility mapping (QSM) of the human kidney Bechler, Eric Stabinska, Julia Thiel, Thomas Jasse, Jonas Zukovs, Romans Valentin, Birte Wittsack, Hans-Jörg Ljimani, Alexandra MAGMA Research Article OBJECTIVE: To evaluate the feasibility of in-vivo quantitative susceptibility mapping (QSM) of the human kidney. METHODS: An axial single-breath-hold 3D multi-echo sequence (acquisition time 33 s) was completed on a 3 T-MRI-scanner (Magnetom Prisma, Siemens Healthineers, Erlangen, Germany) in 19 healthy volunteers. Graph-cut-based unwrapping combined with the T(2)*-IDEAL approach was performed to remove the chemical shift of fat and to quantify QSM of the upper abdomen. Mean susceptibility values of the entire, renal cortex and medulla in both kidneys and the liver were determined and compared. Five subjects were measured twice to examine the reproducibility. One patient with severe renal fibrosis was included in the study to evaluate the potential clinical relevance of QSM. RESULTS: QSM was successful in 17 volunteers and the patient with renal fibrosis. Anatomical structures in the abdomen were clearly distinguishable by QSM and the susceptibility values obtained in the liver were comparable to those found in the literature. The results showed a good reproducibility. Besides, the mean renal QSM values obtained in healthy volunteers (0.04 ± 0.07 ppm for the right and − 0.06 ± 0.19 ppm for the left kidney) were substantially higher than that measured in the investigated fibrotic kidney (− 0.43 ± − 0.02 ppm). CONCLUSION: QSM of the human kidney could be a promising approach for the assessment of information about microscopic renal tissue structure. Therefore, it might further improve functional renal MR imaging. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10334-020-00895-9) contains supplementary material, which is available to authorized users. Springer International Publishing 2020-11-24 2021 /pmc/articles/PMC8492554/ /pubmed/33230656 http://dx.doi.org/10.1007/s10334-020-00895-9 Text en © The Author(s) 2020, , corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Bechler, Eric Stabinska, Julia Thiel, Thomas Jasse, Jonas Zukovs, Romans Valentin, Birte Wittsack, Hans-Jörg Ljimani, Alexandra Feasibility of quantitative susceptibility mapping (QSM) of the human kidney |
title | Feasibility of quantitative susceptibility mapping (QSM) of the human kidney |
title_full | Feasibility of quantitative susceptibility mapping (QSM) of the human kidney |
title_fullStr | Feasibility of quantitative susceptibility mapping (QSM) of the human kidney |
title_full_unstemmed | Feasibility of quantitative susceptibility mapping (QSM) of the human kidney |
title_short | Feasibility of quantitative susceptibility mapping (QSM) of the human kidney |
title_sort | feasibility of quantitative susceptibility mapping (qsm) of the human kidney |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492554/ https://www.ncbi.nlm.nih.gov/pubmed/33230656 http://dx.doi.org/10.1007/s10334-020-00895-9 |
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