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Melatonin and doxorubicin synergistically enhance apoptosis via autophagy-dependent reduction of AMPKα1 transcription in human breast cancer cells

Doxorubicin is one of the most effective agents used to treat various cancers, including breast cancer, but its usage is limited by the risk of adverse effects, including cardiotoxicity. Melatonin, a natural hormone that functions as a major regulator of circadian rhythms, has been considered a supp...

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Detalles Bibliográficos
Autores principales: Tran, Quynh Hoa, Hoang, Dang Hieu, Song, Minhyeok, Choe, Wonchae, Kang, Insug, Kim, Sung Soo, Ha, Joohun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492618/
https://www.ncbi.nlm.nih.gov/pubmed/34584194
http://dx.doi.org/10.1038/s12276-021-00675-y