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Fetuin-B, a potential link of liver-adipose tissue cross talk during diet-induced weight loss–weight maintenance

BACKGROUND/OBJECTIVES: Numerous hepatokines are involved in inter-organ cross talk regulating tissue-specific insulin sensitivity. Adipose tissue lipolysis represents a crucial element of adipose insulin sensitivity and is substantially involved in long-term body weight regulation after dietary weig...

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Autores principales: Li, Linna, Spranger, Leonard, Stobäus, Nicole, Beer, Finja, Decker, Anne-Marie, Wernicke, Charlotte, Brachs, Sebastian, Brachs, Maria, Spranger, Joachim, Mai, Knut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492646/
https://www.ncbi.nlm.nih.gov/pubmed/34611132
http://dx.doi.org/10.1038/s41387-021-00174-z
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author Li, Linna
Spranger, Leonard
Stobäus, Nicole
Beer, Finja
Decker, Anne-Marie
Wernicke, Charlotte
Brachs, Sebastian
Brachs, Maria
Spranger, Joachim
Mai, Knut
author_facet Li, Linna
Spranger, Leonard
Stobäus, Nicole
Beer, Finja
Decker, Anne-Marie
Wernicke, Charlotte
Brachs, Sebastian
Brachs, Maria
Spranger, Joachim
Mai, Knut
author_sort Li, Linna
collection PubMed
description BACKGROUND/OBJECTIVES: Numerous hepatokines are involved in inter-organ cross talk regulating tissue-specific insulin sensitivity. Adipose tissue lipolysis represents a crucial element of adipose insulin sensitivity and is substantially involved in long-term body weight regulation after dietary weight loss. Thus, we aimed to analyze the impact of the hepatokine Fetuin-B in the context of weight loss induced short- and long-term modulation of adipose insulin sensitivity. SUBJECTS/METHODS: 143 subjects (age > 18; BMI ≥ 27 kg/m(2)) were analyzed before (T-3) and after (T0) a standardized 12-week dietary weight reduction program. Afterward, subjects were randomized to a 12-month lifestyle intervention or a control group. After 12 months (T12) no further intervention was performed until 6 months later (T18) (Maintain-Adults trial). Tissue-specific insulin sensitivity was estimated by HOMA-IR (predominantly liver), ISI(Clamp) (predominantly skeletal muscle), and free fatty acid suppression during hyperinsulinemic-euglycemic clamp (FFA(Supp)) (predominantly adipose tissue). Fetuin-B was measured at all concomitant time points. RESULTS: Circulating Fetuin-B levels correlated significantly with estimates of obesity, hepatic steatosis as well as HOMA-IR, ISI(Clamp), FFA(Supp) at baseline. Fetuin-B decreased during dietary weight loss (4.2 (3.5–4.9) vs. 3.8 (3.2–4.6) µg/ml; p = 2.1 × 10(−5)). This change was associated with concomitant improvement of HOMA-IR (r = 0.222; p = 0.008) and FFA(Supp) (r = −0.210; p = 0.013), suggesting a particular relationship to hepatic and adipose tissue insulin sensitivity. Weight loss induced improvements of insulin resistance were almost completely preserved until months 12 and 18 and most interestingly, the short and long-term improvement of FFA(Supp) was partially predicted by baseline level of Fetuin-B. CONCLUSIONS: Our data suggest that Fetuin-B might be a potential mediator of liver-adipose cross talk involved in short- and long-term regulation of adipose insulin sensitivity, especially in the context of diet-induced weight changes. TRIAL REGISTRATION: ClinicalTrials.gov number: NCT00850629, https://clinicaltrials.gov/ct2/show/NCT00850629, date of registration: February 25, 2009.
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spelling pubmed-84926462021-10-07 Fetuin-B, a potential link of liver-adipose tissue cross talk during diet-induced weight loss–weight maintenance Li, Linna Spranger, Leonard Stobäus, Nicole Beer, Finja Decker, Anne-Marie Wernicke, Charlotte Brachs, Sebastian Brachs, Maria Spranger, Joachim Mai, Knut Nutr Diabetes Article BACKGROUND/OBJECTIVES: Numerous hepatokines are involved in inter-organ cross talk regulating tissue-specific insulin sensitivity. Adipose tissue lipolysis represents a crucial element of adipose insulin sensitivity and is substantially involved in long-term body weight regulation after dietary weight loss. Thus, we aimed to analyze the impact of the hepatokine Fetuin-B in the context of weight loss induced short- and long-term modulation of adipose insulin sensitivity. SUBJECTS/METHODS: 143 subjects (age > 18; BMI ≥ 27 kg/m(2)) were analyzed before (T-3) and after (T0) a standardized 12-week dietary weight reduction program. Afterward, subjects were randomized to a 12-month lifestyle intervention or a control group. After 12 months (T12) no further intervention was performed until 6 months later (T18) (Maintain-Adults trial). Tissue-specific insulin sensitivity was estimated by HOMA-IR (predominantly liver), ISI(Clamp) (predominantly skeletal muscle), and free fatty acid suppression during hyperinsulinemic-euglycemic clamp (FFA(Supp)) (predominantly adipose tissue). Fetuin-B was measured at all concomitant time points. RESULTS: Circulating Fetuin-B levels correlated significantly with estimates of obesity, hepatic steatosis as well as HOMA-IR, ISI(Clamp), FFA(Supp) at baseline. Fetuin-B decreased during dietary weight loss (4.2 (3.5–4.9) vs. 3.8 (3.2–4.6) µg/ml; p = 2.1 × 10(−5)). This change was associated with concomitant improvement of HOMA-IR (r = 0.222; p = 0.008) and FFA(Supp) (r = −0.210; p = 0.013), suggesting a particular relationship to hepatic and adipose tissue insulin sensitivity. Weight loss induced improvements of insulin resistance were almost completely preserved until months 12 and 18 and most interestingly, the short and long-term improvement of FFA(Supp) was partially predicted by baseline level of Fetuin-B. CONCLUSIONS: Our data suggest that Fetuin-B might be a potential mediator of liver-adipose cross talk involved in short- and long-term regulation of adipose insulin sensitivity, especially in the context of diet-induced weight changes. TRIAL REGISTRATION: ClinicalTrials.gov number: NCT00850629, https://clinicaltrials.gov/ct2/show/NCT00850629, date of registration: February 25, 2009. Nature Publishing Group UK 2021-10-05 /pmc/articles/PMC8492646/ /pubmed/34611132 http://dx.doi.org/10.1038/s41387-021-00174-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Li, Linna
Spranger, Leonard
Stobäus, Nicole
Beer, Finja
Decker, Anne-Marie
Wernicke, Charlotte
Brachs, Sebastian
Brachs, Maria
Spranger, Joachim
Mai, Knut
Fetuin-B, a potential link of liver-adipose tissue cross talk during diet-induced weight loss–weight maintenance
title Fetuin-B, a potential link of liver-adipose tissue cross talk during diet-induced weight loss–weight maintenance
title_full Fetuin-B, a potential link of liver-adipose tissue cross talk during diet-induced weight loss–weight maintenance
title_fullStr Fetuin-B, a potential link of liver-adipose tissue cross talk during diet-induced weight loss–weight maintenance
title_full_unstemmed Fetuin-B, a potential link of liver-adipose tissue cross talk during diet-induced weight loss–weight maintenance
title_short Fetuin-B, a potential link of liver-adipose tissue cross talk during diet-induced weight loss–weight maintenance
title_sort fetuin-b, a potential link of liver-adipose tissue cross talk during diet-induced weight loss–weight maintenance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492646/
https://www.ncbi.nlm.nih.gov/pubmed/34611132
http://dx.doi.org/10.1038/s41387-021-00174-z
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