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Machine learning-guided acyl-ACP reductase engineering for improved in vivo fatty alcohol production

Alcohol-forming fatty acyl reductases (FARs) catalyze the reduction of thioesters to alcohols and are key enzymes for microbial production of fatty alcohols. Many metabolic engineering strategies utilize FARs to produce fatty alcohols from intracellular acyl-CoA and acyl-ACP pools; however, enzyme a...

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Detalles Bibliográficos
Autores principales:	Greenhalgh, Jonathan C., Fahlberg, Sarah A., Pfleger, Brian F., Romero, Philip A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492656/ https://www.ncbi.nlm.nih.gov/pubmed/34611172 http://dx.doi.org/10.1038/s41467-021-25831-w

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