Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy

Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer mortality by 2030. Bulk transcriptomic analyses have distinguished ‘classical’ from ‘basal-like’ tumors with more aggressive clinical behavior. We derive PDAC organoids from 18 primary tumors and two matche...

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Detalles Bibliográficos
Autores principales: Krieger, Teresa G., Le Blanc, Solange, Jabs, Julia, Ten, Foo Wei, Ishaque, Naveed, Jechow, Katharina, Debnath, Olivia, Leonhardt, Carl-Stephan, Giri, Anamika, Eils, Roland, Strobel, Oliver, Conrad, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492851/
https://www.ncbi.nlm.nih.gov/pubmed/34611171
http://dx.doi.org/10.1038/s41467-021-26059-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492851/
https://www.ncbi.nlm.nih.gov/pubmed/34611171
http://dx.doi.org/10.1038/s41467-021-26059-4

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