Cargando…

Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV

There is an urgent need to understand the nature of immune responses against SARS-CoV-2, to inform risk-mitigation strategies for people living with HIV (PLWH). Here we show that the majority of PLWH with ART suppressed HIV viral load, mount a detectable adaptive immune response to SARS-CoV-2. Humor...

Descripción completa

Detalles Bibliográficos
Autores principales: Alrubayyi, Aljawharah, Gea-Mallorquí, Ester, Touizer, Emma, Hameiri-Bowen, Dan, Kopycinski, Jakub, Charlton, Bethany, Fisher-Pearson, Natasha, Muir, Luke, Rosa, Annachiara, Roustan, Chloe, Earl, Christopher, Cherepanov, Peter, Pellegrino, Pierre, Waters, Laura, Burns, Fiona, Kinloch, Sabine, Dong, Tao, Dorrell, Lucy, Rowland-Jones, Sarah, McCoy, Laura E., Peppa, Dimitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492866/
https://www.ncbi.nlm.nih.gov/pubmed/34611163
http://dx.doi.org/10.1038/s41467-021-26137-7
_version_ 1784579004975546368
author Alrubayyi, Aljawharah
Gea-Mallorquí, Ester
Touizer, Emma
Hameiri-Bowen, Dan
Kopycinski, Jakub
Charlton, Bethany
Fisher-Pearson, Natasha
Muir, Luke
Rosa, Annachiara
Roustan, Chloe
Earl, Christopher
Cherepanov, Peter
Pellegrino, Pierre
Waters, Laura
Burns, Fiona
Kinloch, Sabine
Dong, Tao
Dorrell, Lucy
Rowland-Jones, Sarah
McCoy, Laura E.
Peppa, Dimitra
author_facet Alrubayyi, Aljawharah
Gea-Mallorquí, Ester
Touizer, Emma
Hameiri-Bowen, Dan
Kopycinski, Jakub
Charlton, Bethany
Fisher-Pearson, Natasha
Muir, Luke
Rosa, Annachiara
Roustan, Chloe
Earl, Christopher
Cherepanov, Peter
Pellegrino, Pierre
Waters, Laura
Burns, Fiona
Kinloch, Sabine
Dong, Tao
Dorrell, Lucy
Rowland-Jones, Sarah
McCoy, Laura E.
Peppa, Dimitra
author_sort Alrubayyi, Aljawharah
collection PubMed
description There is an urgent need to understand the nature of immune responses against SARS-CoV-2, to inform risk-mitigation strategies for people living with HIV (PLWH). Here we show that the majority of PLWH with ART suppressed HIV viral load, mount a detectable adaptive immune response to SARS-CoV-2. Humoral and SARS-CoV-2-specific T cell responses are comparable between HIV-positive and negative subjects and persist 5-7 months following predominately mild COVID-19 disease. T cell responses against Spike, Membrane and Nucleoprotein are the most prominent, with SARS-CoV-2-specific CD4 T cells outnumbering CD8 T cells. We further show that the overall magnitude of SARS-CoV-2-specific T cell responses relates to the size of the naive CD4 T cell pool and the CD4:CD8 ratio in PLWH. These findings suggest that inadequate immune reconstitution on ART, could hinder immune responses to SARS-CoV-2 with implications for the individual management and vaccine effectiveness in PLWH.
format Online
Article
Text
id pubmed-8492866
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-84928662021-10-07 Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV Alrubayyi, Aljawharah Gea-Mallorquí, Ester Touizer, Emma Hameiri-Bowen, Dan Kopycinski, Jakub Charlton, Bethany Fisher-Pearson, Natasha Muir, Luke Rosa, Annachiara Roustan, Chloe Earl, Christopher Cherepanov, Peter Pellegrino, Pierre Waters, Laura Burns, Fiona Kinloch, Sabine Dong, Tao Dorrell, Lucy Rowland-Jones, Sarah McCoy, Laura E. Peppa, Dimitra Nat Commun Article There is an urgent need to understand the nature of immune responses against SARS-CoV-2, to inform risk-mitigation strategies for people living with HIV (PLWH). Here we show that the majority of PLWH with ART suppressed HIV viral load, mount a detectable adaptive immune response to SARS-CoV-2. Humoral and SARS-CoV-2-specific T cell responses are comparable between HIV-positive and negative subjects and persist 5-7 months following predominately mild COVID-19 disease. T cell responses against Spike, Membrane and Nucleoprotein are the most prominent, with SARS-CoV-2-specific CD4 T cells outnumbering CD8 T cells. We further show that the overall magnitude of SARS-CoV-2-specific T cell responses relates to the size of the naive CD4 T cell pool and the CD4:CD8 ratio in PLWH. These findings suggest that inadequate immune reconstitution on ART, could hinder immune responses to SARS-CoV-2 with implications for the individual management and vaccine effectiveness in PLWH. Nature Publishing Group UK 2021-10-05 /pmc/articles/PMC8492866/ /pubmed/34611163 http://dx.doi.org/10.1038/s41467-021-26137-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Alrubayyi, Aljawharah
Gea-Mallorquí, Ester
Touizer, Emma
Hameiri-Bowen, Dan
Kopycinski, Jakub
Charlton, Bethany
Fisher-Pearson, Natasha
Muir, Luke
Rosa, Annachiara
Roustan, Chloe
Earl, Christopher
Cherepanov, Peter
Pellegrino, Pierre
Waters, Laura
Burns, Fiona
Kinloch, Sabine
Dong, Tao
Dorrell, Lucy
Rowland-Jones, Sarah
McCoy, Laura E.
Peppa, Dimitra
Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV
title Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV
title_full Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV
title_fullStr Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV
title_full_unstemmed Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV
title_short Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV
title_sort characterization of humoral and sars-cov-2 specific t cell responses in people living with hiv
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492866/
https://www.ncbi.nlm.nih.gov/pubmed/34611163
http://dx.doi.org/10.1038/s41467-021-26137-7
work_keys_str_mv AT alrubayyialjawharah characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT geamallorquiester characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT touizeremma characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT hameiribowendan characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT kopycinskijakub characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT charltonbethany characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT fisherpearsonnatasha characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT muirluke characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT rosaannachiara characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT roustanchloe characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT earlchristopher characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT cherepanovpeter characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT pellegrinopierre characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT waterslaura characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT burnsfiona characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT kinlochsabine characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT dongtao characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT dorrelllucy characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT rowlandjonessarah characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT mccoylaurae characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv
AT peppadimitra characterizationofhumoralandsarscov2specifictcellresponsesinpeoplelivingwithhiv