Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes

Obesity is now recognized as a disease. This study revealed a novel role for pyruvate dehydrogenase kinase (PDK) in diet-induced hypertrophic obesity. Mice with global or adipose tissue-specific PDK2 deficiency were protected against diet-induced obesity. The weight of adipose tissues and the size o...

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Detalles Bibliográficos
Autores principales: Kang, Hyeon-Ji, Min, Byong-Keol, Choi, Won-Il, Jeon, Jae-Han, Kim, Dong Wook, Park, Sungmi, Lee, Yun-Kyung, Kim, Hwa-jin, Byeon, Ju-Eun, Go, Younghoon, Ham, Hye Jin, Jeon, Yong Hyun, Kim, Mi-Jin, Lee, Jung Yi, Wende, Adam R., Choi, Sung Hee, Harris, Robert A., Lee, In-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492875/
https://www.ncbi.nlm.nih.gov/pubmed/34552205
http://dx.doi.org/10.1038/s12276-021-00672-1

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