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The Effect of Different Head Movement Paradigms on Vestibulo-Ocular Reflex Gain and Saccadic Eye Responses in the Suppression Head Impulse Test in Healthy Adult Volunteers
Objective: This study aimed to identify differences in vestibulo-ocular reflex gain (VOR gain) and saccadic response in the suppression head impulse paradigm (SHIMP) between predictable and less predictable head movements, in a group of healthy subjects. It was hypothesized that higher prediction co...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492894/ https://www.ncbi.nlm.nih.gov/pubmed/34630303 http://dx.doi.org/10.3389/fneur.2021.729081 |
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author | Starkov, Dmitrii Vermorken, Bernd Van Dooren, T. S. Van Stiphout, Lisa Janssen, Miranda Pleshkov, Maksim Guinand, Nils Pérez Fornos, Angelica Van Rompaey, Vincent Kingma, Herman Van de Berg, Raymond |
author_facet | Starkov, Dmitrii Vermorken, Bernd Van Dooren, T. S. Van Stiphout, Lisa Janssen, Miranda Pleshkov, Maksim Guinand, Nils Pérez Fornos, Angelica Van Rompaey, Vincent Kingma, Herman Van de Berg, Raymond |
author_sort | Starkov, Dmitrii |
collection | PubMed |
description | Objective: This study aimed to identify differences in vestibulo-ocular reflex gain (VOR gain) and saccadic response in the suppression head impulse paradigm (SHIMP) between predictable and less predictable head movements, in a group of healthy subjects. It was hypothesized that higher prediction could lead to a lower VOR gain, a shorter saccadic latency, and higher grouping of saccades. Methods: Sixty-two healthy subjects were tested using the video head impulse test and SHIMPs in four conditions: active and passive head movements for both inward and outward directions. VOR gain, latency of the first saccade, and the level of saccade grouping (PR-score) were compared among conditions. Inward and active head movements were considered to be more predictable than outward and passive head movements. Results: After validation, results of 57 tested subjects were analyzed. Mean VOR gain was significantly lower for inward passive compared with outward passive head impulses (p < 0.001), and it was higher for active compared with passive head impulses (both inward and outward) (p ≤ 0.024). Mean latency of the first saccade was significantly shorter for inward active compared with inward passive (p ≤ 0.001) and for inward passive compared with outward passive head impulses (p = 0.012). Mean PR-score was only significantly higher in active outward than in active inward head impulses (p = 0.004). Conclusion: For SHIMP, a higher predictability in head movements lowered gain only in passive impulses and shortened latencies of compensatory saccades overall. For active impulses, gain calculation was affected by short-latency compensatory saccades, hindering reliable comparison with gains of passive impulses. Predictability did not substantially influence grouping of compensatory saccades. |
format | Online Article Text |
id | pubmed-8492894 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84928942021-10-07 The Effect of Different Head Movement Paradigms on Vestibulo-Ocular Reflex Gain and Saccadic Eye Responses in the Suppression Head Impulse Test in Healthy Adult Volunteers Starkov, Dmitrii Vermorken, Bernd Van Dooren, T. S. Van Stiphout, Lisa Janssen, Miranda Pleshkov, Maksim Guinand, Nils Pérez Fornos, Angelica Van Rompaey, Vincent Kingma, Herman Van de Berg, Raymond Front Neurol Neurology Objective: This study aimed to identify differences in vestibulo-ocular reflex gain (VOR gain) and saccadic response in the suppression head impulse paradigm (SHIMP) between predictable and less predictable head movements, in a group of healthy subjects. It was hypothesized that higher prediction could lead to a lower VOR gain, a shorter saccadic latency, and higher grouping of saccades. Methods: Sixty-two healthy subjects were tested using the video head impulse test and SHIMPs in four conditions: active and passive head movements for both inward and outward directions. VOR gain, latency of the first saccade, and the level of saccade grouping (PR-score) were compared among conditions. Inward and active head movements were considered to be more predictable than outward and passive head movements. Results: After validation, results of 57 tested subjects were analyzed. Mean VOR gain was significantly lower for inward passive compared with outward passive head impulses (p < 0.001), and it was higher for active compared with passive head impulses (both inward and outward) (p ≤ 0.024). Mean latency of the first saccade was significantly shorter for inward active compared with inward passive (p ≤ 0.001) and for inward passive compared with outward passive head impulses (p = 0.012). Mean PR-score was only significantly higher in active outward than in active inward head impulses (p = 0.004). Conclusion: For SHIMP, a higher predictability in head movements lowered gain only in passive impulses and shortened latencies of compensatory saccades overall. For active impulses, gain calculation was affected by short-latency compensatory saccades, hindering reliable comparison with gains of passive impulses. Predictability did not substantially influence grouping of compensatory saccades. Frontiers Media S.A. 2021-09-22 /pmc/articles/PMC8492894/ /pubmed/34630303 http://dx.doi.org/10.3389/fneur.2021.729081 Text en Copyright © 2021 Starkov, Vermorken, Van Dooren, Van Stiphout, Janssen, Pleshkov, Guinand, Pérez Fornos, Van Rompaey, Kingma and Van de Berg. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Starkov, Dmitrii Vermorken, Bernd Van Dooren, T. S. Van Stiphout, Lisa Janssen, Miranda Pleshkov, Maksim Guinand, Nils Pérez Fornos, Angelica Van Rompaey, Vincent Kingma, Herman Van de Berg, Raymond The Effect of Different Head Movement Paradigms on Vestibulo-Ocular Reflex Gain and Saccadic Eye Responses in the Suppression Head Impulse Test in Healthy Adult Volunteers |
title | The Effect of Different Head Movement Paradigms on Vestibulo-Ocular Reflex Gain and Saccadic Eye Responses in the Suppression Head Impulse Test in Healthy Adult Volunteers |
title_full | The Effect of Different Head Movement Paradigms on Vestibulo-Ocular Reflex Gain and Saccadic Eye Responses in the Suppression Head Impulse Test in Healthy Adult Volunteers |
title_fullStr | The Effect of Different Head Movement Paradigms on Vestibulo-Ocular Reflex Gain and Saccadic Eye Responses in the Suppression Head Impulse Test in Healthy Adult Volunteers |
title_full_unstemmed | The Effect of Different Head Movement Paradigms on Vestibulo-Ocular Reflex Gain and Saccadic Eye Responses in the Suppression Head Impulse Test in Healthy Adult Volunteers |
title_short | The Effect of Different Head Movement Paradigms on Vestibulo-Ocular Reflex Gain and Saccadic Eye Responses in the Suppression Head Impulse Test in Healthy Adult Volunteers |
title_sort | effect of different head movement paradigms on vestibulo-ocular reflex gain and saccadic eye responses in the suppression head impulse test in healthy adult volunteers |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492894/ https://www.ncbi.nlm.nih.gov/pubmed/34630303 http://dx.doi.org/10.3389/fneur.2021.729081 |
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