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Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report

Background: Ruminant species are at risk of developing abomasal ulceration, but there is a lack of pharmacokinetic data for anti-ulcer therapies, such as the proton pump inhibitor pantoprazole, in goats. Objective: The primary study objective was to estimate the plasma pharmacokinetic parameters for...

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Autores principales: Smith, Joe S., Mochel, Jonathan P., Soto-Gonzalez, Windy M., Rahn, Rebecca R., Fayne, Bryanna N., Escher, Olivia G., Geletka, Anastasia M., Harvill, Lainey E., Bergman, Joan B., Cox, Sherry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492921/
https://www.ncbi.nlm.nih.gov/pubmed/34631865
http://dx.doi.org/10.3389/fvets.2021.744813
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author Smith, Joe S.
Mochel, Jonathan P.
Soto-Gonzalez, Windy M.
Rahn, Rebecca R.
Fayne, Bryanna N.
Escher, Olivia G.
Geletka, Anastasia M.
Harvill, Lainey E.
Bergman, Joan B.
Cox, Sherry
author_facet Smith, Joe S.
Mochel, Jonathan P.
Soto-Gonzalez, Windy M.
Rahn, Rebecca R.
Fayne, Bryanna N.
Escher, Olivia G.
Geletka, Anastasia M.
Harvill, Lainey E.
Bergman, Joan B.
Cox, Sherry
author_sort Smith, Joe S.
collection PubMed
description Background: Ruminant species are at risk of developing abomasal ulceration, but there is a lack of pharmacokinetic data for anti-ulcer therapies, such as the proton pump inhibitor pantoprazole, in goats. Objective: The primary study objective was to estimate the plasma pharmacokinetic parameters for pantoprazole in adult goats after intravenous administration. A secondary objective was to describe the pharmacokinetic parameters for the metabolite, pantoprazole sulfone, in goats. Methods: Pantoprazole was administered intravenously to six adult goats at a dose of 1 mg/kg. Plasma samples were collected over 36h and analyzed via reverse phase high performance liquid chromatography for determination of pantoprazole and pantoprazole sulfone concentrations. Pharmacokinetic parameters were determined by non-compartmental analysis. Results: Plasma clearance, elimination half-life, and volume of distribution of pantoprazole were estimated at 0.345 mL/kg/min, 0.7 h, and 0.9 L/kg, respectively following IV administration. The maximum concentration, elimination half-life and area under the curve of pantoprazole sulfone were estimated at 0.1 μg/mL, 0.8 h, and 0.2 hr(*)μg/mL, respectively. The global extraction ratio was estimated 0.00795 ± 0.00138. All animals had normal physical examinations after conclusion of the study. Conclusion: The reported plasma clearance for pantoprazole is lower than reported for foals, calves, and alpacas. The elimination half-life appears to be < that reported for foals and calves. Future pharmacodynamic studies are necessary for determination of the efficacy of pantoprazole on acid suppression in goats.
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spelling pubmed-84929212021-10-07 Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report Smith, Joe S. Mochel, Jonathan P. Soto-Gonzalez, Windy M. Rahn, Rebecca R. Fayne, Bryanna N. Escher, Olivia G. Geletka, Anastasia M. Harvill, Lainey E. Bergman, Joan B. Cox, Sherry Front Vet Sci Veterinary Science Background: Ruminant species are at risk of developing abomasal ulceration, but there is a lack of pharmacokinetic data for anti-ulcer therapies, such as the proton pump inhibitor pantoprazole, in goats. Objective: The primary study objective was to estimate the plasma pharmacokinetic parameters for pantoprazole in adult goats after intravenous administration. A secondary objective was to describe the pharmacokinetic parameters for the metabolite, pantoprazole sulfone, in goats. Methods: Pantoprazole was administered intravenously to six adult goats at a dose of 1 mg/kg. Plasma samples were collected over 36h and analyzed via reverse phase high performance liquid chromatography for determination of pantoprazole and pantoprazole sulfone concentrations. Pharmacokinetic parameters were determined by non-compartmental analysis. Results: Plasma clearance, elimination half-life, and volume of distribution of pantoprazole were estimated at 0.345 mL/kg/min, 0.7 h, and 0.9 L/kg, respectively following IV administration. The maximum concentration, elimination half-life and area under the curve of pantoprazole sulfone were estimated at 0.1 μg/mL, 0.8 h, and 0.2 hr(*)μg/mL, respectively. The global extraction ratio was estimated 0.00795 ± 0.00138. All animals had normal physical examinations after conclusion of the study. Conclusion: The reported plasma clearance for pantoprazole is lower than reported for foals, calves, and alpacas. The elimination half-life appears to be < that reported for foals and calves. Future pharmacodynamic studies are necessary for determination of the efficacy of pantoprazole on acid suppression in goats. Frontiers Media S.A. 2021-09-22 /pmc/articles/PMC8492921/ /pubmed/34631865 http://dx.doi.org/10.3389/fvets.2021.744813 Text en Copyright © 2021 Smith, Mochel, Soto-Gonzalez, Rahn, Fayne, Escher, Geletka, Harvill, Bergman and Cox. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Smith, Joe S.
Mochel, Jonathan P.
Soto-Gonzalez, Windy M.
Rahn, Rebecca R.
Fayne, Bryanna N.
Escher, Olivia G.
Geletka, Anastasia M.
Harvill, Lainey E.
Bergman, Joan B.
Cox, Sherry
Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report
title Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report
title_full Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report
title_fullStr Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report
title_full_unstemmed Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report
title_short Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report
title_sort pharmacokinetics of pantoprazole and pantoprazole sulfone in goats after intravenous administration: a preliminary report
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492921/
https://www.ncbi.nlm.nih.gov/pubmed/34631865
http://dx.doi.org/10.3389/fvets.2021.744813
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