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Application of Proteomics in Cancer: Recent Trends and Approaches for Biomarkers Discovery
Proteomics has become an important field in molecular sciences, as it provides valuable information on the identity, expression levels, and modification of proteins. For example, cancer proteomics unraveled key information in mechanistic studies on tumor growth and metastasis, which has contributed...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492935/ https://www.ncbi.nlm.nih.gov/pubmed/34631760 http://dx.doi.org/10.3389/fmed.2021.747333 |
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author | Kwon, Yang Woo Jo, Han-Seul Bae, Sungwon Seo, Youngsuk Song, Parkyong Song, Minseok Yoon, Jong Hyuk |
author_facet | Kwon, Yang Woo Jo, Han-Seul Bae, Sungwon Seo, Youngsuk Song, Parkyong Song, Minseok Yoon, Jong Hyuk |
author_sort | Kwon, Yang Woo |
collection | PubMed |
description | Proteomics has become an important field in molecular sciences, as it provides valuable information on the identity, expression levels, and modification of proteins. For example, cancer proteomics unraveled key information in mechanistic studies on tumor growth and metastasis, which has contributed to the identification of clinically applicable biomarkers as well as therapeutic targets. Several cancer proteome databases have been established and are being shared worldwide. Importantly, the integration of proteomics studies with other omics is providing extensive data related to molecular mechanisms and target modulators. These data may be analyzed and processed through bioinformatic pipelines to obtain useful information. The purpose of this review is to provide an overview of cancer proteomics and recent advances in proteomic techniques. In particular, we aim to offer insights into current proteomics studies of brain cancer, in which proteomic applications are in a relatively early stage. This review covers applications of proteomics from the discovery of biomarkers to the characterization of molecular mechanisms through advances in technology. Moreover, it addresses global trends in proteomics approaches for translational research. As a core method in translational research, the continued development of this field is expected to provide valuable information at a scale beyond that previously seen. |
format | Online Article Text |
id | pubmed-8492935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84929352021-10-07 Application of Proteomics in Cancer: Recent Trends and Approaches for Biomarkers Discovery Kwon, Yang Woo Jo, Han-Seul Bae, Sungwon Seo, Youngsuk Song, Parkyong Song, Minseok Yoon, Jong Hyuk Front Med (Lausanne) Medicine Proteomics has become an important field in molecular sciences, as it provides valuable information on the identity, expression levels, and modification of proteins. For example, cancer proteomics unraveled key information in mechanistic studies on tumor growth and metastasis, which has contributed to the identification of clinically applicable biomarkers as well as therapeutic targets. Several cancer proteome databases have been established and are being shared worldwide. Importantly, the integration of proteomics studies with other omics is providing extensive data related to molecular mechanisms and target modulators. These data may be analyzed and processed through bioinformatic pipelines to obtain useful information. The purpose of this review is to provide an overview of cancer proteomics and recent advances in proteomic techniques. In particular, we aim to offer insights into current proteomics studies of brain cancer, in which proteomic applications are in a relatively early stage. This review covers applications of proteomics from the discovery of biomarkers to the characterization of molecular mechanisms through advances in technology. Moreover, it addresses global trends in proteomics approaches for translational research. As a core method in translational research, the continued development of this field is expected to provide valuable information at a scale beyond that previously seen. Frontiers Media S.A. 2021-09-22 /pmc/articles/PMC8492935/ /pubmed/34631760 http://dx.doi.org/10.3389/fmed.2021.747333 Text en Copyright © 2021 Kwon, Jo, Bae, Seo, Song, Song and Yoon. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Kwon, Yang Woo Jo, Han-Seul Bae, Sungwon Seo, Youngsuk Song, Parkyong Song, Minseok Yoon, Jong Hyuk Application of Proteomics in Cancer: Recent Trends and Approaches for Biomarkers Discovery |
title | Application of Proteomics in Cancer: Recent Trends and Approaches for Biomarkers Discovery |
title_full | Application of Proteomics in Cancer: Recent Trends and Approaches for Biomarkers Discovery |
title_fullStr | Application of Proteomics in Cancer: Recent Trends and Approaches for Biomarkers Discovery |
title_full_unstemmed | Application of Proteomics in Cancer: Recent Trends and Approaches for Biomarkers Discovery |
title_short | Application of Proteomics in Cancer: Recent Trends and Approaches for Biomarkers Discovery |
title_sort | application of proteomics in cancer: recent trends and approaches for biomarkers discovery |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492935/ https://www.ncbi.nlm.nih.gov/pubmed/34631760 http://dx.doi.org/10.3389/fmed.2021.747333 |
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