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Case Report: Complex Congenital Brain Anomaly in a BBxHF Calf–Clinical Signs, Magnetic Resonance Imaging, and Pathological Findings

This case report describes the clinical signs, magnetic resonance imaging (MRI) findings and associated (histo)pathological findings in a crossbred Belgian Blue calf with congenital complex brain anomaly. The calf was presented with non-progressive signs (including cerebellar ataxia) since it was bo...

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Autores principales: Veenema, Neeltje J., Santifort, Koen M., Kuijpers, Nienke W., Seijger, Anne, Hut, Peter R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492953/
https://www.ncbi.nlm.nih.gov/pubmed/34631846
http://dx.doi.org/10.3389/fvets.2021.700527
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author Veenema, Neeltje J.
Santifort, Koen M.
Kuijpers, Nienke W.
Seijger, Anne
Hut, Peter R.
author_facet Veenema, Neeltje J.
Santifort, Koen M.
Kuijpers, Nienke W.
Seijger, Anne
Hut, Peter R.
author_sort Veenema, Neeltje J.
collection PubMed
description This case report describes the clinical signs, magnetic resonance imaging (MRI) findings and associated (histo)pathological findings in a crossbred Belgian Blue calf with congenital complex brain anomaly. The calf was presented with non-progressive signs (including cerebellar ataxia) since it was born, suggestive of a multifocal intracranial lesion. A congenital anomaly was suspected and after hematology, biochemistry, serology, and cerebrospinal fluid analysis, a magnetic resonance imaging study was performed. The following suspected abnormalities were the principal changes identified: severe hydrocephalus, porencephaly, suspected partial corpus callosum agenesis (CCA), and increased fluid signal between the folia of the cerebellum. Post-mortem examination predominately reflected the MRI findings. The origin for these malformations could not be identified and there was no evidence of a causative infectious agent. Corpus callosum abnormalities have been reported in bovids before and have been linked to bovine viral diarrhea virus (BVDV) infections, as have several other central nervous system anomalies in this species. In this case, BVDV was deemed an unlikely causative agent based on serology test results and lack of typical histopathological signs. The etiology of the congenital anomaly present in this bovine calf remains unknown.
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spelling pubmed-84929532021-10-07 Case Report: Complex Congenital Brain Anomaly in a BBxHF Calf–Clinical Signs, Magnetic Resonance Imaging, and Pathological Findings Veenema, Neeltje J. Santifort, Koen M. Kuijpers, Nienke W. Seijger, Anne Hut, Peter R. Front Vet Sci Veterinary Science This case report describes the clinical signs, magnetic resonance imaging (MRI) findings and associated (histo)pathological findings in a crossbred Belgian Blue calf with congenital complex brain anomaly. The calf was presented with non-progressive signs (including cerebellar ataxia) since it was born, suggestive of a multifocal intracranial lesion. A congenital anomaly was suspected and after hematology, biochemistry, serology, and cerebrospinal fluid analysis, a magnetic resonance imaging study was performed. The following suspected abnormalities were the principal changes identified: severe hydrocephalus, porencephaly, suspected partial corpus callosum agenesis (CCA), and increased fluid signal between the folia of the cerebellum. Post-mortem examination predominately reflected the MRI findings. The origin for these malformations could not be identified and there was no evidence of a causative infectious agent. Corpus callosum abnormalities have been reported in bovids before and have been linked to bovine viral diarrhea virus (BVDV) infections, as have several other central nervous system anomalies in this species. In this case, BVDV was deemed an unlikely causative agent based on serology test results and lack of typical histopathological signs. The etiology of the congenital anomaly present in this bovine calf remains unknown. Frontiers Media S.A. 2021-09-22 /pmc/articles/PMC8492953/ /pubmed/34631846 http://dx.doi.org/10.3389/fvets.2021.700527 Text en Copyright © 2021 Veenema, Santifort, Kuijpers, Seijger and Hut. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Veenema, Neeltje J.
Santifort, Koen M.
Kuijpers, Nienke W.
Seijger, Anne
Hut, Peter R.
Case Report: Complex Congenital Brain Anomaly in a BBxHF Calf–Clinical Signs, Magnetic Resonance Imaging, and Pathological Findings
title Case Report: Complex Congenital Brain Anomaly in a BBxHF Calf–Clinical Signs, Magnetic Resonance Imaging, and Pathological Findings
title_full Case Report: Complex Congenital Brain Anomaly in a BBxHF Calf–Clinical Signs, Magnetic Resonance Imaging, and Pathological Findings
title_fullStr Case Report: Complex Congenital Brain Anomaly in a BBxHF Calf–Clinical Signs, Magnetic Resonance Imaging, and Pathological Findings
title_full_unstemmed Case Report: Complex Congenital Brain Anomaly in a BBxHF Calf–Clinical Signs, Magnetic Resonance Imaging, and Pathological Findings
title_short Case Report: Complex Congenital Brain Anomaly in a BBxHF Calf–Clinical Signs, Magnetic Resonance Imaging, and Pathological Findings
title_sort case report: complex congenital brain anomaly in a bbxhf calf–clinical signs, magnetic resonance imaging, and pathological findings
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492953/
https://www.ncbi.nlm.nih.gov/pubmed/34631846
http://dx.doi.org/10.3389/fvets.2021.700527
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