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Clinical Predictors of Wheezing Among Children Infected With Mycoplasma Pneumoniae

Background:Mycoplasma pneumoniae (MP) not only was a common pathogen of respiratory tract infections, but also could trigger the exacerbation of asthmatic symptoms in children with or without asthma. Objective: This study aimed to identify possible risk factors associated with wheezing among childre...

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Autores principales: Kong, Kaimeng, Ding, Ying, Wu, Beirong, Lu, Min, Gu, Haoxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492963/
https://www.ncbi.nlm.nih.gov/pubmed/34631611
http://dx.doi.org/10.3389/fped.2021.693658
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author Kong, Kaimeng
Ding, Ying
Wu, Beirong
Lu, Min
Gu, Haoxiang
author_facet Kong, Kaimeng
Ding, Ying
Wu, Beirong
Lu, Min
Gu, Haoxiang
author_sort Kong, Kaimeng
collection PubMed
description Background:Mycoplasma pneumoniae (MP) not only was a common pathogen of respiratory tract infections, but also could trigger the exacerbation of asthmatic symptoms in children with or without asthma. Objective: This study aimed to identify possible risk factors associated with wheezing among children diagnosed with MP infection. Methods: A retrospective analysis of medical records of children aged 28 days to 18 years old who visited the Shanghai Children's Hospital between January 2019 and January 2020 was carried out, and all children were then classified into three groups: two wheezing groups (with or without MP infection) and a non-wheezing group with MP infection. Information including patient's demographics, clinical features, laboratory data, and radiography findings was extracted from the electronic medical record system. Chest radiographs were reviewed independently by two board-certified, blinded pediatric radiologists. Results: A total of 1,512 patients were included in our study, and 21.9% of them belonged to the wheezing group without MP infection. Among 1,181 patients with MP infection, 295 people (25.0%) suffered from wheezing, and males accounted for 61%. Through the multivariable logistic regression analyses, we found that six variables were positively associated with wheezing attacks in children with MP infection: male gender (likelihood ratio [LR] = 2.124, 95% confidence interval [CI]: 1.478–3.053), history of allergy (LR= 3.301, 95% CI: 2.206–4.941), history of wheezing (LR = 7.808, 95% CI: 5.276–11.557), autumn in reference to summer (LR = 2.414, 95% CI: 1.500–3.885), non-end-point infiltration in reference to consolidation or pleural effusion (LR = 1.982, 95% CI: 1.348–2.914), and infiltration scope (LR = 1.773, 95% CI: 1.293–2.432). However, the model showed that the probability of wheezing after MP infection decreased as age increased (LR = 0.257, 95% CI: 0.196–0.337). Moreover, the area under the curve (AUC) of the regression model was as high as 0.901 (0.847–0.955). Conclusion: The model integrated with factors including gender, age, season, radiological patterns, infiltration scope, and history of allergy performed well in predicting wheezing attack after MP infection in children.
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spelling pubmed-84929632021-10-07 Clinical Predictors of Wheezing Among Children Infected With Mycoplasma Pneumoniae Kong, Kaimeng Ding, Ying Wu, Beirong Lu, Min Gu, Haoxiang Front Pediatr Pediatrics Background:Mycoplasma pneumoniae (MP) not only was a common pathogen of respiratory tract infections, but also could trigger the exacerbation of asthmatic symptoms in children with or without asthma. Objective: This study aimed to identify possible risk factors associated with wheezing among children diagnosed with MP infection. Methods: A retrospective analysis of medical records of children aged 28 days to 18 years old who visited the Shanghai Children's Hospital between January 2019 and January 2020 was carried out, and all children were then classified into three groups: two wheezing groups (with or without MP infection) and a non-wheezing group with MP infection. Information including patient's demographics, clinical features, laboratory data, and radiography findings was extracted from the electronic medical record system. Chest radiographs were reviewed independently by two board-certified, blinded pediatric radiologists. Results: A total of 1,512 patients were included in our study, and 21.9% of them belonged to the wheezing group without MP infection. Among 1,181 patients with MP infection, 295 people (25.0%) suffered from wheezing, and males accounted for 61%. Through the multivariable logistic regression analyses, we found that six variables were positively associated with wheezing attacks in children with MP infection: male gender (likelihood ratio [LR] = 2.124, 95% confidence interval [CI]: 1.478–3.053), history of allergy (LR= 3.301, 95% CI: 2.206–4.941), history of wheezing (LR = 7.808, 95% CI: 5.276–11.557), autumn in reference to summer (LR = 2.414, 95% CI: 1.500–3.885), non-end-point infiltration in reference to consolidation or pleural effusion (LR = 1.982, 95% CI: 1.348–2.914), and infiltration scope (LR = 1.773, 95% CI: 1.293–2.432). However, the model showed that the probability of wheezing after MP infection decreased as age increased (LR = 0.257, 95% CI: 0.196–0.337). Moreover, the area under the curve (AUC) of the regression model was as high as 0.901 (0.847–0.955). Conclusion: The model integrated with factors including gender, age, season, radiological patterns, infiltration scope, and history of allergy performed well in predicting wheezing attack after MP infection in children. Frontiers Media S.A. 2021-09-22 /pmc/articles/PMC8492963/ /pubmed/34631611 http://dx.doi.org/10.3389/fped.2021.693658 Text en Copyright © 2021 Kong, Ding, Wu, Lu and Gu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Kong, Kaimeng
Ding, Ying
Wu, Beirong
Lu, Min
Gu, Haoxiang
Clinical Predictors of Wheezing Among Children Infected With Mycoplasma Pneumoniae
title Clinical Predictors of Wheezing Among Children Infected With Mycoplasma Pneumoniae
title_full Clinical Predictors of Wheezing Among Children Infected With Mycoplasma Pneumoniae
title_fullStr Clinical Predictors of Wheezing Among Children Infected With Mycoplasma Pneumoniae
title_full_unstemmed Clinical Predictors of Wheezing Among Children Infected With Mycoplasma Pneumoniae
title_short Clinical Predictors of Wheezing Among Children Infected With Mycoplasma Pneumoniae
title_sort clinical predictors of wheezing among children infected with mycoplasma pneumoniae
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492963/
https://www.ncbi.nlm.nih.gov/pubmed/34631611
http://dx.doi.org/10.3389/fped.2021.693658
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