Cargando…

Genotype Distribution Change After Human Papillomavirus Vaccination in Two Autonomous Communities in Spain

CONTEXT: It has been more than 10 years since the human papillomavirus (HPV) vaccination program was initiated in most advanced countries. Thus, it seems necessary to change the uterine cervical cancer screening strategy. Molecular-based tests are considered essential in this scenario. OBJECTIVE: We...

Descripción completa

Detalles Bibliográficos
Autores principales: Freire-Salinas, Javier, Benito, Rafael, Azueta, Ainara, Gil, Joaquina, Mendoza, Claudia, Nicolás, Montserrat, García-Berbel, Pilar, Algarate, Sonia, Gómez-Román, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493034/
https://www.ncbi.nlm.nih.gov/pubmed/34631594
http://dx.doi.org/10.3389/fcimb.2021.633162
_version_ 1784579044213260288
author Freire-Salinas, Javier
Benito, Rafael
Azueta, Ainara
Gil, Joaquina
Mendoza, Claudia
Nicolás, Montserrat
García-Berbel, Pilar
Algarate, Sonia
Gómez-Román, Javier
author_facet Freire-Salinas, Javier
Benito, Rafael
Azueta, Ainara
Gil, Joaquina
Mendoza, Claudia
Nicolás, Montserrat
García-Berbel, Pilar
Algarate, Sonia
Gómez-Román, Javier
author_sort Freire-Salinas, Javier
collection PubMed
description CONTEXT: It has been more than 10 years since the human papillomavirus (HPV) vaccination program was initiated in most advanced countries. Thus, it seems necessary to change the uterine cervical cancer screening strategy. Molecular-based tests are considered essential in this scenario. OBJECTIVE: We aimed to review the distribution of the HPV genotypes after the introduction of the vaccination program with Cervarix® and Gardasil 4® in two autonomous communities in Spain, looking for possible changes in distribution and the occurrence of a herd effect. DESIGN: A cross-sectional study was performed in 45,362 samples that were processed in the Cantabria and Aragon communities during the period from 2002 to 2016. We compared the genotype distribution before and after the vaccination program was initiated. RESULTS: Genotypes HPV6 and HPV11 have decreased significantly after the introduction of the vaccine. HPV16 has had a decrease, but not a significant one in the statistical analysis. However, HPV31, HPV52, and HPV45 have increased in percentage. A replacement phenomenon with other genotypes not included in the vaccine has been observed in our population. CONCLUSIONS: Continued surveillance is needed to provide further indication of any changes over time in the genotypes in circulation. This will be facilitated by monitoring the genotyping results from the new model of cervical screening using primary HPV DNA testing.
format Online
Article
Text
id pubmed-8493034
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-84930342021-10-07 Genotype Distribution Change After Human Papillomavirus Vaccination in Two Autonomous Communities in Spain Freire-Salinas, Javier Benito, Rafael Azueta, Ainara Gil, Joaquina Mendoza, Claudia Nicolás, Montserrat García-Berbel, Pilar Algarate, Sonia Gómez-Román, Javier Front Cell Infect Microbiol Cellular and Infection Microbiology CONTEXT: It has been more than 10 years since the human papillomavirus (HPV) vaccination program was initiated in most advanced countries. Thus, it seems necessary to change the uterine cervical cancer screening strategy. Molecular-based tests are considered essential in this scenario. OBJECTIVE: We aimed to review the distribution of the HPV genotypes after the introduction of the vaccination program with Cervarix® and Gardasil 4® in two autonomous communities in Spain, looking for possible changes in distribution and the occurrence of a herd effect. DESIGN: A cross-sectional study was performed in 45,362 samples that were processed in the Cantabria and Aragon communities during the period from 2002 to 2016. We compared the genotype distribution before and after the vaccination program was initiated. RESULTS: Genotypes HPV6 and HPV11 have decreased significantly after the introduction of the vaccine. HPV16 has had a decrease, but not a significant one in the statistical analysis. However, HPV31, HPV52, and HPV45 have increased in percentage. A replacement phenomenon with other genotypes not included in the vaccine has been observed in our population. CONCLUSIONS: Continued surveillance is needed to provide further indication of any changes over time in the genotypes in circulation. This will be facilitated by monitoring the genotyping results from the new model of cervical screening using primary HPV DNA testing. Frontiers Media S.A. 2021-09-22 /pmc/articles/PMC8493034/ /pubmed/34631594 http://dx.doi.org/10.3389/fcimb.2021.633162 Text en Copyright © 2021 Freire-Salinas, Benito, Azueta, Gil, Mendoza, Nicolás, García-Berbel, Algarate and Gómez-Román https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Freire-Salinas, Javier
Benito, Rafael
Azueta, Ainara
Gil, Joaquina
Mendoza, Claudia
Nicolás, Montserrat
García-Berbel, Pilar
Algarate, Sonia
Gómez-Román, Javier
Genotype Distribution Change After Human Papillomavirus Vaccination in Two Autonomous Communities in Spain
title Genotype Distribution Change After Human Papillomavirus Vaccination in Two Autonomous Communities in Spain
title_full Genotype Distribution Change After Human Papillomavirus Vaccination in Two Autonomous Communities in Spain
title_fullStr Genotype Distribution Change After Human Papillomavirus Vaccination in Two Autonomous Communities in Spain
title_full_unstemmed Genotype Distribution Change After Human Papillomavirus Vaccination in Two Autonomous Communities in Spain
title_short Genotype Distribution Change After Human Papillomavirus Vaccination in Two Autonomous Communities in Spain
title_sort genotype distribution change after human papillomavirus vaccination in two autonomous communities in spain
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493034/
https://www.ncbi.nlm.nih.gov/pubmed/34631594
http://dx.doi.org/10.3389/fcimb.2021.633162
work_keys_str_mv AT freiresalinasjavier genotypedistributionchangeafterhumanpapillomavirusvaccinationintwoautonomouscommunitiesinspain
AT benitorafael genotypedistributionchangeafterhumanpapillomavirusvaccinationintwoautonomouscommunitiesinspain
AT azuetaainara genotypedistributionchangeafterhumanpapillomavirusvaccinationintwoautonomouscommunitiesinspain
AT giljoaquina genotypedistributionchangeafterhumanpapillomavirusvaccinationintwoautonomouscommunitiesinspain
AT mendozaclaudia genotypedistributionchangeafterhumanpapillomavirusvaccinationintwoautonomouscommunitiesinspain
AT nicolasmontserrat genotypedistributionchangeafterhumanpapillomavirusvaccinationintwoautonomouscommunitiesinspain
AT garciaberbelpilar genotypedistributionchangeafterhumanpapillomavirusvaccinationintwoautonomouscommunitiesinspain
AT algaratesonia genotypedistributionchangeafterhumanpapillomavirusvaccinationintwoautonomouscommunitiesinspain
AT gomezromanjavier genotypedistributionchangeafterhumanpapillomavirusvaccinationintwoautonomouscommunitiesinspain