Transgenic Mice Overexpressing Human Alpha-1 Antitrypsin Exhibit Low Blood Pressure and Altered Epithelial Transport Mechanisms in the Inactive and Active Cycles

Human alpha-1 antitrypsin (hAAT) is a versatile protease inhibitor, but little is known about its targets in the aldosterone-sensitive distal nephron and its role in electrolyte balance and blood pressure control. We analyzed urinary electrolytes, osmolality, and blood pressure from hAAT transgenic...

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Detalles Bibliográficos
Autores principales: Liu, Lauren P., Gholam, Mohammed F., Elshikha, Ahmed Samir, Kawakibi, Tamim, Elmoujahid, Nasseem, Moussa, Hassan H., Song, Sihong, Alli, Abdel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493122/
https://www.ncbi.nlm.nih.gov/pubmed/34630137
http://dx.doi.org/10.3389/fphys.2021.710313

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