Hemophagocytic Lymphohistiocytosis Induced by Epstein-Barr Virus Infection and Newly Diagnosed Hodgkin Lymphoma

Hemophagocytic lymphohistiocytosis (HLH) is a rare, but life-threatening disorder of pathologic immune system activation which results in a hyperinflammatory state. Previous studies have suggested that hematologic malignancies are often inciting factors for HLH and portend a poorer prognosis. However, the substantial overlap between features of hematologic malignancies and HLH makes recognition and prompt diagnosis of HLH a complex and difficult task. We present a case of a young male who presented with acute dyspnea on exertion, unintentional weight loss, and fatigue. He was found to have pancytopenia, fever, splenomegaly, and Epstein-Barr viremia and was subsequently diagnosed with nodular sclerosing Hodgkin lymphoma. Five of eight 2004-HLH criteria were met and the patient was started on intravenous dexamethasone (10 mg/m(2) daily), acyclovir, and AAVD (brentuximab, doxorubicin, vinblastine, dacarbazine) chemotherapy protocol with improvement in his symptoms and laboratory findings.