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There is no “origin” to SARS-CoV-2

Since the beginning of the COVID-19 pandemic in 2020 caused by SARS-CoV-2, the question of the origin of this virus has been a highly debated issue. Debates have been, and are still, very disputed and often violent between the two main hypotheses: a natural origin through the “spillover” model or a...

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Autores principales: Frutos, Roger, Pliez, Olivier, Gavotte, Laurent, Devaux, Christian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493644/
https://www.ncbi.nlm.nih.gov/pubmed/34626592
http://dx.doi.org/10.1016/j.envres.2021.112173
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author Frutos, Roger
Pliez, Olivier
Gavotte, Laurent
Devaux, Christian A.
author_facet Frutos, Roger
Pliez, Olivier
Gavotte, Laurent
Devaux, Christian A.
author_sort Frutos, Roger
collection PubMed
description Since the beginning of the COVID-19 pandemic in 2020 caused by SARS-CoV-2, the question of the origin of this virus has been a highly debated issue. Debates have been, and are still, very disputed and often violent between the two main hypotheses: a natural origin through the “spillover” model or a laboratory-leak origin. Tenants of these two options are building arguments often based on the discrepancies of the other theory. The main problem is that it is the initial question of the origin itself which is biased. Charles Darwin demonstrated in 1859 that all species are appearing through a process of evolution, adaptation and selection. There is no determined origin to any animal or plant species, simply an evolutionary and selective process in which chance and environment play a key role. The very same is true for viruses. There is no determined origin to viruses, simply also an evolutionary and selective process in which chance and environment play a key role. However, in the case of viruses the process is slightly more complex because the “environment” is another living organism. Pandemic viruses already circulate in humans prior to the emergence of a disease. They are simply not capable of triggering an epidemic yet. They must evolve in-host, i.e. in-humans, for that. The evolutionary process which gave rise to SARS-CoV-2 is still ongoing with regular emergence of novel variants more adapted than the previous ones. The real relevant question is how these viruses can emerge as pandemic viruses and what the society can do to prevent the future emergence of pandemic viruses.
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spelling pubmed-84936442021-10-06 There is no “origin” to SARS-CoV-2 Frutos, Roger Pliez, Olivier Gavotte, Laurent Devaux, Christian A. Environ Res Article Since the beginning of the COVID-19 pandemic in 2020 caused by SARS-CoV-2, the question of the origin of this virus has been a highly debated issue. Debates have been, and are still, very disputed and often violent between the two main hypotheses: a natural origin through the “spillover” model or a laboratory-leak origin. Tenants of these two options are building arguments often based on the discrepancies of the other theory. The main problem is that it is the initial question of the origin itself which is biased. Charles Darwin demonstrated in 1859 that all species are appearing through a process of evolution, adaptation and selection. There is no determined origin to any animal or plant species, simply an evolutionary and selective process in which chance and environment play a key role. The very same is true for viruses. There is no determined origin to viruses, simply also an evolutionary and selective process in which chance and environment play a key role. However, in the case of viruses the process is slightly more complex because the “environment” is another living organism. Pandemic viruses already circulate in humans prior to the emergence of a disease. They are simply not capable of triggering an epidemic yet. They must evolve in-host, i.e. in-humans, for that. The evolutionary process which gave rise to SARS-CoV-2 is still ongoing with regular emergence of novel variants more adapted than the previous ones. The real relevant question is how these viruses can emerge as pandemic viruses and what the society can do to prevent the future emergence of pandemic viruses. The Authors. Published by Elsevier Inc. 2022-05-01 2021-10-06 /pmc/articles/PMC8493644/ /pubmed/34626592 http://dx.doi.org/10.1016/j.envres.2021.112173 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Frutos, Roger
Pliez, Olivier
Gavotte, Laurent
Devaux, Christian A.
There is no “origin” to SARS-CoV-2
title There is no “origin” to SARS-CoV-2
title_full There is no “origin” to SARS-CoV-2
title_fullStr There is no “origin” to SARS-CoV-2
title_full_unstemmed There is no “origin” to SARS-CoV-2
title_short There is no “origin” to SARS-CoV-2
title_sort there is no “origin” to sars-cov-2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493644/
https://www.ncbi.nlm.nih.gov/pubmed/34626592
http://dx.doi.org/10.1016/j.envres.2021.112173
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