A fungal antigenic driver for Löfgren’s syndrome sarcoidosis

Löfgren’s syndrome is an acute form of sarcoidosis that is characterized by the activation of CD4(+) T helper cells. In this issue of JEM, Greaves et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20210785) identified a peptide derived from an airborne mold species that stimulates T cells of Lö...

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Detalles Bibliográficos
Autores principales: Lim, Clarice X., Weichhart, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493861/
https://www.ncbi.nlm.nih.gov/pubmed/34515726
http://dx.doi.org/10.1084/jem.20211572
Descripción
Sumario:Löfgren’s syndrome is an acute form of sarcoidosis that is characterized by the activation of CD4(+) T helper cells. In this issue of JEM, Greaves et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20210785) identified a peptide derived from an airborne mold species that stimulates T cells of Löfgren’s syndrome patients in an HLA-DR3–restricted manner. An increased serum IgG antibody response to the full-length protein was also observed in those patients, indicating that the fungus Aspergillus nidulans might be the elusive microbial agent that drives acute sarcoidosis.

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