A fungal antigenic driver for Löfgren’s syndrome sarcoidosis

Löfgren’s syndrome is an acute form of sarcoidosis that is characterized by the activation of CD4(+) T helper cells. In this issue of JEM, Greaves et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20210785) identified a peptide derived from an airborne mold species that stimulates T cells of Lö...

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Detalles Bibliográficos
Autores principales: Lim, Clarice X., Weichhart, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493861/
https://www.ncbi.nlm.nih.gov/pubmed/34515726
http://dx.doi.org/10.1084/jem.20211572
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author Lim, Clarice X.
Weichhart, Thomas
author_facet Lim, Clarice X.
Weichhart, Thomas
author_sort Lim, Clarice X.
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description Löfgren’s syndrome is an acute form of sarcoidosis that is characterized by the activation of CD4(+) T helper cells. In this issue of JEM, Greaves et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20210785) identified a peptide derived from an airborne mold species that stimulates T cells of Löfgren’s syndrome patients in an HLA-DR3–restricted manner. An increased serum IgG antibody response to the full-length protein was also observed in those patients, indicating that the fungus Aspergillus nidulans might be the elusive microbial agent that drives acute sarcoidosis.
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spelling pubmed-84938612022-04-04 A fungal antigenic driver for Löfgren’s syndrome sarcoidosis Lim, Clarice X. Weichhart, Thomas J Exp Med Insights Löfgren’s syndrome is an acute form of sarcoidosis that is characterized by the activation of CD4(+) T helper cells. In this issue of JEM, Greaves et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20210785) identified a peptide derived from an airborne mold species that stimulates T cells of Löfgren’s syndrome patients in an HLA-DR3–restricted manner. An increased serum IgG antibody response to the full-length protein was also observed in those patients, indicating that the fungus Aspergillus nidulans might be the elusive microbial agent that drives acute sarcoidosis. Rockefeller University Press 2021-09-13 /pmc/articles/PMC8493861/ /pubmed/34515726 http://dx.doi.org/10.1084/jem.20211572 Text en © 2021 Lim and Weichhart http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Lim, Clarice X.
Weichhart, Thomas
A fungal antigenic driver for Löfgren’s syndrome sarcoidosis
title A fungal antigenic driver for Löfgren’s syndrome sarcoidosis
title_full A fungal antigenic driver for Löfgren’s syndrome sarcoidosis
title_fullStr A fungal antigenic driver for Löfgren’s syndrome sarcoidosis
title_full_unstemmed A fungal antigenic driver for Löfgren’s syndrome sarcoidosis
title_short A fungal antigenic driver for Löfgren’s syndrome sarcoidosis
title_sort fungal antigenic driver for löfgren’s syndrome sarcoidosis
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493861/
https://www.ncbi.nlm.nih.gov/pubmed/34515726
http://dx.doi.org/10.1084/jem.20211572
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