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Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis
Blood transcriptomics have revealed major characteristics of the immune response in active TB, but the signature early after infection is unknown. In a unique clinically and temporally well-defined cohort of household contacts of active TB patients that progressed to TB, we define minimal changes in...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493863/ https://www.ncbi.nlm.nih.gov/pubmed/34491266 http://dx.doi.org/10.1084/jem.20210915 |
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author | Tabone, Olivier Verma, Raman Singhania, Akul Chakravarty, Probir Branchett, William J. Graham, Christine M. Lee, Jo Trang, Tran Reynier, Frederic Leissner, Philippe Kaiser, Karine Rodrigue, Marc Woltmann, Gerrit Haldar, Pranabashis O’Garra, Anne |
author_facet | Tabone, Olivier Verma, Raman Singhania, Akul Chakravarty, Probir Branchett, William J. Graham, Christine M. Lee, Jo Trang, Tran Reynier, Frederic Leissner, Philippe Kaiser, Karine Rodrigue, Marc Woltmann, Gerrit Haldar, Pranabashis O’Garra, Anne |
author_sort | Tabone, Olivier |
collection | PubMed |
description | Blood transcriptomics have revealed major characteristics of the immune response in active TB, but the signature early after infection is unknown. In a unique clinically and temporally well-defined cohort of household contacts of active TB patients that progressed to TB, we define minimal changes in gene expression in incipient TB increasing in subclinical and clinical TB. While increasing with time, changes in gene expression were highest at 30 d before diagnosis, with heterogeneity in the response in household TB contacts and in a published cohort of TB progressors as they progressed to TB, at a bulk cohort level and in individual progressors. Blood signatures from patients before and during anti-TB treatment robustly monitored the treatment response distinguishing early and late responders. Blood transcriptomics thus reveal the evolution and resolution of the immune response in TB, which may help in clinical management of the disease. |
format | Online Article Text |
id | pubmed-8493863 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-84938632021-10-07 Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis Tabone, Olivier Verma, Raman Singhania, Akul Chakravarty, Probir Branchett, William J. Graham, Christine M. Lee, Jo Trang, Tran Reynier, Frederic Leissner, Philippe Kaiser, Karine Rodrigue, Marc Woltmann, Gerrit Haldar, Pranabashis O’Garra, Anne J Exp Med Article Blood transcriptomics have revealed major characteristics of the immune response in active TB, but the signature early after infection is unknown. In a unique clinically and temporally well-defined cohort of household contacts of active TB patients that progressed to TB, we define minimal changes in gene expression in incipient TB increasing in subclinical and clinical TB. While increasing with time, changes in gene expression were highest at 30 d before diagnosis, with heterogeneity in the response in household TB contacts and in a published cohort of TB progressors as they progressed to TB, at a bulk cohort level and in individual progressors. Blood signatures from patients before and during anti-TB treatment robustly monitored the treatment response distinguishing early and late responders. Blood transcriptomics thus reveal the evolution and resolution of the immune response in TB, which may help in clinical management of the disease. Rockefeller University Press 2021-09-07 /pmc/articles/PMC8493863/ /pubmed/34491266 http://dx.doi.org/10.1084/jem.20210915 Text en © 2021 Tabone et al. https://creativecommons.org/licenses/by/4.0/This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tabone, Olivier Verma, Raman Singhania, Akul Chakravarty, Probir Branchett, William J. Graham, Christine M. Lee, Jo Trang, Tran Reynier, Frederic Leissner, Philippe Kaiser, Karine Rodrigue, Marc Woltmann, Gerrit Haldar, Pranabashis O’Garra, Anne Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis |
title | Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis |
title_full | Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis |
title_fullStr | Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis |
title_full_unstemmed | Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis |
title_short | Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis |
title_sort | blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493863/ https://www.ncbi.nlm.nih.gov/pubmed/34491266 http://dx.doi.org/10.1084/jem.20210915 |
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