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Anaesthetic protocol for paediatric glaucoma examinations: the prospective EyeBIS Study protocol
INTRODUCTION: Neonates and young infants with diagnosed or highly suspected glaucoma require an examination under anaesthesia to achieve accurate intraocular pressure (IOP) measurements, since crying or squinting of the eyes may increase IOP and lead to falsely high values. IOP considerably depends...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493900/ https://www.ncbi.nlm.nih.gov/pubmed/34610927 http://dx.doi.org/10.1136/bmjopen-2020-045906 |
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author | Pirlich, Nina Grehn, Franz Mohnke, Katja Maucher, Konrad Schuster, Alexander Wittenmeier, Eva Schmidtmann, Irene Hoffmann, Esther M |
author_facet | Pirlich, Nina Grehn, Franz Mohnke, Katja Maucher, Konrad Schuster, Alexander Wittenmeier, Eva Schmidtmann, Irene Hoffmann, Esther M |
author_sort | Pirlich, Nina |
collection | PubMed |
description | INTRODUCTION: Neonates and young infants with diagnosed or highly suspected glaucoma require an examination under anaesthesia to achieve accurate intraocular pressure (IOP) measurements, since crying or squinting of the eyes may increase IOP and lead to falsely high values. IOP considerably depends on perioperative variables such as haemodynamic factors, anaesthetics, depth of anaesthesia and airway management. The aim of this paper is to report the design and baseline characteristics of EyeBIS, which is a study to develop a standardised anaesthetic protocol for the measurement of IOP under anaesthesia in childhood glaucoma, by investigating the link between the magnitude of IOP and depth of anaesthesia. METHODS AND ANALYSIS: This is a single-centre, prospective cohort study in 100 children with diagnosed or highly suspected glaucoma all undergoing ophthalmological examination under general anaesthesia. 20 children, who undergo general anaesthesia for other reasons, are included as controls. The primary outcome measure is the establishment of a standardised anaesthetic protocol for IOP measurement in childhood glaucoma by assessing the relationship between IOP and depth of anaesthesia (calculated as an electroencephalography variable, the bispectral index), with special emphasis on airway management and haemodynamic parameters. The dependence of IOP under anaesthesia on airway management and haemodynamic parameters will be described, using a mixed linear model. Restricting the model to patients with healthy eyes will allow to determine a 95% reference region, in which 95% of the measurement values of patients with healthy eyes can be expected. ETHICS AND DISSEMINATION: The study has been approved by the local ethics committee of the Medical Association of Rhineland-Palatine (Ethik-Kommisssion der Landesaerztekammer Rheinland-Pfalz), Germany (approval number: 2019-14207). This work will be disseminated by publication of peer-reviewed manuscripts, presentation in abstract form at national and international scientific meetings and data sharing with other investigators. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov Registry (NCT03972852). |
format | Online Article Text |
id | pubmed-8493900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-84939002021-10-14 Anaesthetic protocol for paediatric glaucoma examinations: the prospective EyeBIS Study protocol Pirlich, Nina Grehn, Franz Mohnke, Katja Maucher, Konrad Schuster, Alexander Wittenmeier, Eva Schmidtmann, Irene Hoffmann, Esther M BMJ Open Ophthalmology INTRODUCTION: Neonates and young infants with diagnosed or highly suspected glaucoma require an examination under anaesthesia to achieve accurate intraocular pressure (IOP) measurements, since crying or squinting of the eyes may increase IOP and lead to falsely high values. IOP considerably depends on perioperative variables such as haemodynamic factors, anaesthetics, depth of anaesthesia and airway management. The aim of this paper is to report the design and baseline characteristics of EyeBIS, which is a study to develop a standardised anaesthetic protocol for the measurement of IOP under anaesthesia in childhood glaucoma, by investigating the link between the magnitude of IOP and depth of anaesthesia. METHODS AND ANALYSIS: This is a single-centre, prospective cohort study in 100 children with diagnosed or highly suspected glaucoma all undergoing ophthalmological examination under general anaesthesia. 20 children, who undergo general anaesthesia for other reasons, are included as controls. The primary outcome measure is the establishment of a standardised anaesthetic protocol for IOP measurement in childhood glaucoma by assessing the relationship between IOP and depth of anaesthesia (calculated as an electroencephalography variable, the bispectral index), with special emphasis on airway management and haemodynamic parameters. The dependence of IOP under anaesthesia on airway management and haemodynamic parameters will be described, using a mixed linear model. Restricting the model to patients with healthy eyes will allow to determine a 95% reference region, in which 95% of the measurement values of patients with healthy eyes can be expected. ETHICS AND DISSEMINATION: The study has been approved by the local ethics committee of the Medical Association of Rhineland-Palatine (Ethik-Kommisssion der Landesaerztekammer Rheinland-Pfalz), Germany (approval number: 2019-14207). This work will be disseminated by publication of peer-reviewed manuscripts, presentation in abstract form at national and international scientific meetings and data sharing with other investigators. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov Registry (NCT03972852). BMJ Publishing Group 2021-10-05 /pmc/articles/PMC8493900/ /pubmed/34610927 http://dx.doi.org/10.1136/bmjopen-2020-045906 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Ophthalmology Pirlich, Nina Grehn, Franz Mohnke, Katja Maucher, Konrad Schuster, Alexander Wittenmeier, Eva Schmidtmann, Irene Hoffmann, Esther M Anaesthetic protocol for paediatric glaucoma examinations: the prospective EyeBIS Study protocol |
title | Anaesthetic protocol for paediatric glaucoma examinations: the prospective EyeBIS Study protocol |
title_full | Anaesthetic protocol for paediatric glaucoma examinations: the prospective EyeBIS Study protocol |
title_fullStr | Anaesthetic protocol for paediatric glaucoma examinations: the prospective EyeBIS Study protocol |
title_full_unstemmed | Anaesthetic protocol for paediatric glaucoma examinations: the prospective EyeBIS Study protocol |
title_short | Anaesthetic protocol for paediatric glaucoma examinations: the prospective EyeBIS Study protocol |
title_sort | anaesthetic protocol for paediatric glaucoma examinations: the prospective eyebis study protocol |
topic | Ophthalmology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493900/ https://www.ncbi.nlm.nih.gov/pubmed/34610927 http://dx.doi.org/10.1136/bmjopen-2020-045906 |
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