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Nerve density in cancer: Less is better
The density of nerves in cancer is emerging as a relevant clinical parameter for patient survival. Nerves in the tumor microenvironment have been associated with poor survival and recurrence, particularly if involved in perineural invasion. However, usually only a few nerves inside a tumor are affec...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493966/ https://www.ncbi.nlm.nih.gov/pubmed/34632313 http://dx.doi.org/10.1096/fba.2021-00046 |
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author | Schmitd, Ligia B. Perez‐Pacheco, Cindy D'Silva, Nisha J. |
author_facet | Schmitd, Ligia B. Perez‐Pacheco, Cindy D'Silva, Nisha J. |
author_sort | Schmitd, Ligia B. |
collection | PubMed |
description | The density of nerves in cancer is emerging as a relevant clinical parameter for patient survival. Nerves in the tumor microenvironment have been associated with poor survival and recurrence, particularly if involved in perineural invasion. However, usually only a few nerves inside a tumor are affected by perineural invasion, while most nerves are not. Mechanistic studies have shown nerve‐secreted factors promote tumor growth and invasion thereby making tumors more aggressive. Therefore, the overall number of nerves in the tumor microenvironment should be more representative of the nerve‐tumor biological interaction than perineural invasion. This review summarizes the available clinical information about nerve density as a measure of clinical outcome in cancer and explores the mechanisms underlying nerve density in cancer, specifically, neurogenesis, axonogenesis, and neurotropism. |
format | Online Article Text |
id | pubmed-8493966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84939662021-10-08 Nerve density in cancer: Less is better Schmitd, Ligia B. Perez‐Pacheco, Cindy D'Silva, Nisha J. FASEB Bioadv Reviews The density of nerves in cancer is emerging as a relevant clinical parameter for patient survival. Nerves in the tumor microenvironment have been associated with poor survival and recurrence, particularly if involved in perineural invasion. However, usually only a few nerves inside a tumor are affected by perineural invasion, while most nerves are not. Mechanistic studies have shown nerve‐secreted factors promote tumor growth and invasion thereby making tumors more aggressive. Therefore, the overall number of nerves in the tumor microenvironment should be more representative of the nerve‐tumor biological interaction than perineural invasion. This review summarizes the available clinical information about nerve density as a measure of clinical outcome in cancer and explores the mechanisms underlying nerve density in cancer, specifically, neurogenesis, axonogenesis, and neurotropism. John Wiley and Sons Inc. 2021-07-11 /pmc/articles/PMC8493966/ /pubmed/34632313 http://dx.doi.org/10.1096/fba.2021-00046 Text en © 2021 The Authors. FASEB BioAdvances published by Wiley Periodicals LLC on behalf of The Federation of American Societies for Experimental Biology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Reviews Schmitd, Ligia B. Perez‐Pacheco, Cindy D'Silva, Nisha J. Nerve density in cancer: Less is better |
title | Nerve density in cancer: Less is better |
title_full | Nerve density in cancer: Less is better |
title_fullStr | Nerve density in cancer: Less is better |
title_full_unstemmed | Nerve density in cancer: Less is better |
title_short | Nerve density in cancer: Less is better |
title_sort | nerve density in cancer: less is better |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493966/ https://www.ncbi.nlm.nih.gov/pubmed/34632313 http://dx.doi.org/10.1096/fba.2021-00046 |
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