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Disruption of origin chromatin structure by helicase activation in the absence of DNA replication

Prior to initiation of DNA replication, the eukaryotic helicase, Mcm2-7, must be activated to unwind DNA at replication start sites in early S phase. To study helicase activation within origin chromatin, we constructed a conditional mutant of the polymerase α subunit Cdc17 (or Pol1) to prevent primi...

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Detalles Bibliográficos
Autores principales:	Hoffman, Rachel A., MacAlpine, Heather K., MacAlpine, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494203/ https://www.ncbi.nlm.nih.gov/pubmed/34556529 http://dx.doi.org/10.1101/gad.348517.121

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