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Anticipating resistance to KRAS inhibition: a novel role for USP21 in macropinocytosis regulation
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Virtually all PDAC harbors an oncogenic mutation in the KRAS gene, making it the prime target for therapy. Most previous attempts to inhibit KRAS directly have been disappointing, but recent success in targeting some KRAS mutan...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494204/ https://www.ncbi.nlm.nih.gov/pubmed/34599002 http://dx.doi.org/10.1101/gad.348971.121 |