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Role of 53BP1 in end protection and DNA synthesis at DNA breaks

Double-strand break (DSB) repair choice is greatly influenced by the initial processing of DNA ends. 53BP1 limits the formation of recombinogenic single-strand DNA (ssDNA) in BRCA1-deficient cells, leading to defects in homologous recombination (HR). However, the exact mechanisms by which 53BP1 inhi...

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Detalles Bibliográficos
Autores principales:	Paiano, Jacob, Zolnerowich, Nicholas, Wu, Wei, Pavani, Raphael, Wang, Chen, Li, Hongzhi, Zheng, Li, Shen, Binghui, Sleckman, Barry P., Chen, Bo-Ruei, Nussenzweig, André
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494207/ https://www.ncbi.nlm.nih.gov/pubmed/34503990 http://dx.doi.org/10.1101/gad.348667.121

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