Multimodal single-cell/nucleus RNA sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in Alzheimer's disease

Because disease-associated microglia (DAM) and disease-associated astrocytes (DAA) are involved in the pathophysiology of Alzheimer's disease (AD), we systematically identified molecular networks between DAM and DAA to uncover novel therapeutic targets for AD. Specifically, we develop a network...

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Detalles Bibliográficos
Autores principales: Xu, Jielin, Zhang, Pengyue, Huang, Yin, Zhou, Yadi, Hou, Yuan, Bekris, Lynn M., Lathia, Justin, Chiang, Chien-Wei, Li, Lang, Pieper, Andrew A., Leverenz, James B., Cummings, Jeffrey, Cheng, Feixiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494225/
https://www.ncbi.nlm.nih.gov/pubmed/33627474
http://dx.doi.org/10.1101/gr.272484.120

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