ZBP1-MLKL necroptotic signaling potentiates radiation-induced antitumor immunity via intratumoral STING pathway activation

Necroptosis, a form of regulated necrosis, participates in tumor development and dying cell immunogenicity. However, it remains unclear how tumor cell–intrinsic necroptotic signaling contributes to radiation-induced antitumor immunity. Here, we found that the ZBP1-MLKL necroptotic cascade in irradia...

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Detalles Bibliográficos
Autores principales: Yang, Yuanqin, Wu, Meng, Cao, Dongqing, Yang, Chao, Jin, Jingsi, Wu, Lingling, Hong, Xiaochuan, Li, Wenwen, Lu, Lu, Li, Jinmei, Wang, Xinran, Meng, Xiangjiao, Zhang, Zhen, Cheng, Jinke, Ye, Youqiong, Xiao, Hui, Yu, Jinming, Deng, Liufu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494295/
https://www.ncbi.nlm.nih.gov/pubmed/34613770
http://dx.doi.org/10.1126/sciadv.abf6290

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