Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization

Understanding the molecular mechanisms by which antibodies target and neutralize the HIV-1 envelope glycoprotein (Env) is critical in guiding immunogen design and vaccine development aimed at eliciting cross-reactive neutralizing antibodies (NAbs). Here, we analyzed monoclonal antibodies (mAbs) isol...

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Detalles Bibliográficos
Autores principales: Aljedani, Safia S., Liban, Tyler J., Tran, Karen, Phad, Ganesh, Singh, Suruchi, Dubrovskaya, Viktoriya, Pushparaj, Pradeepa, Martinez-Murillo, Paola, Rodarte, Justas, Mileant, Alex, Mangala Prasad, Vidya, Kinzelman, Rachel, O’Dell, Sijy, Mascola, John R., Lee, Kelly K., Karlsson Hedestam, Gunilla B., Wyatt, Richard T., Pancera, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494329/
https://www.ncbi.nlm.nih.gov/pubmed/34559844
http://dx.doi.org/10.1371/journal.ppat.1009543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494329/
https://www.ncbi.nlm.nih.gov/pubmed/34559844
http://dx.doi.org/10.1371/journal.ppat.1009543

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