Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor

Notch signaling controls many developmental processes by regulating gene expression. Notch-dependent enhancers recruit activation complexes consisting of the Notch intracellular domain, the Cbf/Su(H)/Lag1 (CSL) transcription factor (TF), and the Mastermind co-factor via two types of DNA sites: monom...

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Detalles Bibliográficos
Autores principales: Kuang, Yi, Pyo, Anna, Eafergan, Natanel, Cain, Brittany, Gutzwiller, Lisa M., Axelrod, Ofri, Gagliani, Ellen K., Weirauch, Matthew T., Kopan, Raphael, Kovall, Rhett A., Sprinzak, David, Gebelein, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494340/
https://www.ncbi.nlm.nih.gov/pubmed/34559800
http://dx.doi.org/10.1371/journal.pgen.1009039

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