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COVID-19 in lung transplant recipients—Risk prediction and outcomes
Patients after lung transplantation are at risk for life-threatening infections. Recently, several publications on COVID-19 outcomes in this patient population appeared, but knowledge on optimal treatment, mortality, outcomes, and appropriate risk predictors is limited. A retrospective analysis was...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494359/ https://www.ncbi.nlm.nih.gov/pubmed/34613977 http://dx.doi.org/10.1371/journal.pone.0257807 |
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author | Kamp, Jan C. Hinrichs, Jan B. Fuge, Jan Ewen, Raphael Gottlieb, Jens |
author_facet | Kamp, Jan C. Hinrichs, Jan B. Fuge, Jan Ewen, Raphael Gottlieb, Jens |
author_sort | Kamp, Jan C. |
collection | PubMed |
description | Patients after lung transplantation are at risk for life-threatening infections. Recently, several publications on COVID-19 outcomes in this patient population appeared, but knowledge on optimal treatment, mortality, outcomes, and appropriate risk predictors is limited. A retrospective analysis was performed in a German high-volume lung transplant center between 19(th) March 2020 and 18(th) May 2021. Impact of COVID-19 on physical and psychological health, clinical outcomes, and mortality were analyzed including follow-up visits up to 12 weeks after infection in survivors. Predictive parameters on survival were assessed using univariate and multivariate proportional hazards regression models. Out of 1,046 patients in follow-up, 31 acquired COVID-19 during the pandemic. 12 of 31 (39%) died and 26 (84%) were hospitalized. In survivors a significant decline in exercise capacity (p = 0.034), TLC (p = 0.02), and DLCO (p = 0.007) was observed at follow-up after 3 months. Anxiety, depression, and self-assessed quality of life remained stable. Charlson comorbidity index predicted mortality (HR 1.5, 1.1–2.2; p = 0.023). In recipients with pre-existing CLAD, mortality and clinical outcomes were inferior. However, pre-existing CLAD did not predict mortality. COVID-19 remains a life-threatening disease for lung transplant recipients, particularly in case comorbidities. Further studies on long term outcomes and impact on pre-existing CLAD are needed. |
format | Online Article Text |
id | pubmed-8494359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-84943592021-10-07 COVID-19 in lung transplant recipients—Risk prediction and outcomes Kamp, Jan C. Hinrichs, Jan B. Fuge, Jan Ewen, Raphael Gottlieb, Jens PLoS One Research Article Patients after lung transplantation are at risk for life-threatening infections. Recently, several publications on COVID-19 outcomes in this patient population appeared, but knowledge on optimal treatment, mortality, outcomes, and appropriate risk predictors is limited. A retrospective analysis was performed in a German high-volume lung transplant center between 19(th) March 2020 and 18(th) May 2021. Impact of COVID-19 on physical and psychological health, clinical outcomes, and mortality were analyzed including follow-up visits up to 12 weeks after infection in survivors. Predictive parameters on survival were assessed using univariate and multivariate proportional hazards regression models. Out of 1,046 patients in follow-up, 31 acquired COVID-19 during the pandemic. 12 of 31 (39%) died and 26 (84%) were hospitalized. In survivors a significant decline in exercise capacity (p = 0.034), TLC (p = 0.02), and DLCO (p = 0.007) was observed at follow-up after 3 months. Anxiety, depression, and self-assessed quality of life remained stable. Charlson comorbidity index predicted mortality (HR 1.5, 1.1–2.2; p = 0.023). In recipients with pre-existing CLAD, mortality and clinical outcomes were inferior. However, pre-existing CLAD did not predict mortality. COVID-19 remains a life-threatening disease for lung transplant recipients, particularly in case comorbidities. Further studies on long term outcomes and impact on pre-existing CLAD are needed. Public Library of Science 2021-10-06 /pmc/articles/PMC8494359/ /pubmed/34613977 http://dx.doi.org/10.1371/journal.pone.0257807 Text en © 2021 Kamp et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kamp, Jan C. Hinrichs, Jan B. Fuge, Jan Ewen, Raphael Gottlieb, Jens COVID-19 in lung transplant recipients—Risk prediction and outcomes |
title | COVID-19 in lung transplant recipients—Risk prediction and outcomes |
title_full | COVID-19 in lung transplant recipients—Risk prediction and outcomes |
title_fullStr | COVID-19 in lung transplant recipients—Risk prediction and outcomes |
title_full_unstemmed | COVID-19 in lung transplant recipients—Risk prediction and outcomes |
title_short | COVID-19 in lung transplant recipients—Risk prediction and outcomes |
title_sort | covid-19 in lung transplant recipients—risk prediction and outcomes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494359/ https://www.ncbi.nlm.nih.gov/pubmed/34613977 http://dx.doi.org/10.1371/journal.pone.0257807 |
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