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Painful ophthalmoplegia in a patient with a history of marginal zone lymphoma

A 73-year-old man with a history of marginal zone lymphoma was admitted to the emergency room for diplopia and ipsilateral headache. The Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) demonstrated intense and symmetrical hypermetabolism of the cave...

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Autores principales: Van Bogaert, C., Mathey, C., Vierasu, I., Trotta, N., Rocq, L., Wolfromm, A., De Wilde, V., Goldman, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494508/
https://www.ncbi.nlm.nih.gov/pubmed/34617167
http://dx.doi.org/10.1186/s41824-021-00113-2
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author Van Bogaert, C.
Mathey, C.
Vierasu, I.
Trotta, N.
Rocq, L.
Wolfromm, A.
De Wilde, V.
Goldman, S.
author_facet Van Bogaert, C.
Mathey, C.
Vierasu, I.
Trotta, N.
Rocq, L.
Wolfromm, A.
De Wilde, V.
Goldman, S.
author_sort Van Bogaert, C.
collection PubMed
description A 73-year-old man with a history of marginal zone lymphoma was admitted to the emergency room for diplopia and ipsilateral headache. The Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) demonstrated intense and symmetrical hypermetabolism of the cavernous sinuses, and hypermetabolic lesions diffusely in the lymph nodes and bones. The diagnosis of high-grade relapse of lymphomatous disease was made. In this context, the homogenous and symmetric lesion of the cavernous sinuses, without any other encephalic or meningeal lesions, raised the hypothesis of a paraneoplastic origin. A plausible paraneoplastic link between the neuro-ophthalmological lesion and the malignant disorder is IgG4-related disease, a condition that may be associated with lymphoma. As in our case, this diagnosis is often presumptive because histopathological confirmation is difficult to obtain.
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spelling pubmed-84945082021-10-08 Painful ophthalmoplegia in a patient with a history of marginal zone lymphoma Van Bogaert, C. Mathey, C. Vierasu, I. Trotta, N. Rocq, L. Wolfromm, A. De Wilde, V. Goldman, S. Eur J Hybrid Imaging Case Report A 73-year-old man with a history of marginal zone lymphoma was admitted to the emergency room for diplopia and ipsilateral headache. The Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) demonstrated intense and symmetrical hypermetabolism of the cavernous sinuses, and hypermetabolic lesions diffusely in the lymph nodes and bones. The diagnosis of high-grade relapse of lymphomatous disease was made. In this context, the homogenous and symmetric lesion of the cavernous sinuses, without any other encephalic or meningeal lesions, raised the hypothesis of a paraneoplastic origin. A plausible paraneoplastic link between the neuro-ophthalmological lesion and the malignant disorder is IgG4-related disease, a condition that may be associated with lymphoma. As in our case, this diagnosis is often presumptive because histopathological confirmation is difficult to obtain. Springer International Publishing 2021-10-07 /pmc/articles/PMC8494508/ /pubmed/34617167 http://dx.doi.org/10.1186/s41824-021-00113-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Case Report
Van Bogaert, C.
Mathey, C.
Vierasu, I.
Trotta, N.
Rocq, L.
Wolfromm, A.
De Wilde, V.
Goldman, S.
Painful ophthalmoplegia in a patient with a history of marginal zone lymphoma
title Painful ophthalmoplegia in a patient with a history of marginal zone lymphoma
title_full Painful ophthalmoplegia in a patient with a history of marginal zone lymphoma
title_fullStr Painful ophthalmoplegia in a patient with a history of marginal zone lymphoma
title_full_unstemmed Painful ophthalmoplegia in a patient with a history of marginal zone lymphoma
title_short Painful ophthalmoplegia in a patient with a history of marginal zone lymphoma
title_sort painful ophthalmoplegia in a patient with a history of marginal zone lymphoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494508/
https://www.ncbi.nlm.nih.gov/pubmed/34617167
http://dx.doi.org/10.1186/s41824-021-00113-2
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