2020 WHO Classification of Female Genital Tumors

The 2020 WHO classification is focused on the distinction between HPV-associated and HPV-independent squamous cell carcinoma of the lower female genital organs. Differentiating according to HPV association does not replace the process of grading; however, the WHO classification does not recommend an...

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Autores principales: Höhn, Anne Kathrin, Brambs, Christine E., Hiller, Grit Gesine Ruth, May, Doris, Schmoeckel, Elisa, Horn, Lars-Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494521/
https://www.ncbi.nlm.nih.gov/pubmed/34629493
http://dx.doi.org/10.1055/a-1545-4279
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author Höhn, Anne Kathrin
Brambs, Christine E.
Hiller, Grit Gesine Ruth
May, Doris
Schmoeckel, Elisa
Horn, Lars-Christian
author_facet Höhn, Anne Kathrin
Brambs, Christine E.
Hiller, Grit Gesine Ruth
May, Doris
Schmoeckel, Elisa
Horn, Lars-Christian
author_sort Höhn, Anne Kathrin
collection PubMed
description The 2020 WHO classification is focused on the distinction between HPV-associated and HPV-independent squamous cell carcinoma of the lower female genital organs. Differentiating according to HPV association does not replace the process of grading; however, the WHO classification does not recommend any specific grading system. VIN are also differentiated according to whether they are HPV(p16)-associated. HPV-independent adenocarcinoma (AC) of the cervix uteri has an unfavorable prognosis. Immunohistochemical p16 expression is considered to be a surrogate marker for HPV association. HPV-associated AC of the cervix uteri is determined using the prognostically relevant Silva pattern.
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spelling pubmed-84945212021-10-07 2020 WHO Classification of Female Genital Tumors Höhn, Anne Kathrin Brambs, Christine E. Hiller, Grit Gesine Ruth May, Doris Schmoeckel, Elisa Horn, Lars-Christian Geburtshilfe Frauenheilkd The 2020 WHO classification is focused on the distinction between HPV-associated and HPV-independent squamous cell carcinoma of the lower female genital organs. Differentiating according to HPV association does not replace the process of grading; however, the WHO classification does not recommend any specific grading system. VIN are also differentiated according to whether they are HPV(p16)-associated. HPV-independent adenocarcinoma (AC) of the cervix uteri has an unfavorable prognosis. Immunohistochemical p16 expression is considered to be a surrogate marker for HPV association. HPV-associated AC of the cervix uteri is determined using the prognostically relevant Silva pattern. Georg Thieme Verlag KG 2021-10 2021-10-06 /pmc/articles/PMC8494521/ /pubmed/34629493 http://dx.doi.org/10.1055/a-1545-4279 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Höhn, Anne Kathrin
Brambs, Christine E.
Hiller, Grit Gesine Ruth
May, Doris
Schmoeckel, Elisa
Horn, Lars-Christian
2020 WHO Classification of Female Genital Tumors
title 2020 WHO Classification of Female Genital Tumors
title_full 2020 WHO Classification of Female Genital Tumors
title_fullStr 2020 WHO Classification of Female Genital Tumors
title_full_unstemmed 2020 WHO Classification of Female Genital Tumors
title_short 2020 WHO Classification of Female Genital Tumors
title_sort 2020 who classification of female genital tumors
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494521/
https://www.ncbi.nlm.nih.gov/pubmed/34629493
http://dx.doi.org/10.1055/a-1545-4279
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