Cargando…

Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report

PURPOSE: The purpose of this report was to describe the case of a 68-year-old male patient with stage IV colon cancer who exhibited electroretinographic abnormalities that are similar to those of KCNV2 retinopathy. METHODS: The patient presenting with photophobia, reduced visual acuity, and poor gen...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaizuka, Chihiro, Hayashi, Takaaki, Mizobuchi, Kei, Kubota, Masaomi, Ueno, Shinji, Nakano, Tadashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494656/
https://www.ncbi.nlm.nih.gov/pubmed/33738644
http://dx.doi.org/10.1007/s10633-021-09828-w
_version_ 1784579360082100224
author Kaizuka, Chihiro
Hayashi, Takaaki
Mizobuchi, Kei
Kubota, Masaomi
Ueno, Shinji
Nakano, Tadashi
author_facet Kaizuka, Chihiro
Hayashi, Takaaki
Mizobuchi, Kei
Kubota, Masaomi
Ueno, Shinji
Nakano, Tadashi
author_sort Kaizuka, Chihiro
collection PubMed
description PURPOSE: The purpose of this report was to describe the case of a 68-year-old male patient with stage IV colon cancer who exhibited electroretinographic abnormalities that are similar to those of KCNV2 retinopathy. METHODS: The patient presenting with photophobia, reduced visual acuity, and poor general conditions, the onset of which occurred ten days before presentation, was examined using fundoscopy, full-field electroretinography, blood tests, and abdominal computed tomography. RESULTS: The patient’s decimal best-corrected visual acuity (BCVA) was 0.4 in each eye. Fundoscopy showed bull's eye-like maculopathy in both eyes. Electroretinographic findings were similar to the characteristic findings of KCNV2 retinopathy: Rod electroretinogram showed delayed and preserved b-wave amplitudes; bright-flash electroretinogram showed double troughs of a-waves; b/a ratios shown by bright-flash electroretinogram were higher than those shown by standard-flash electroretinogram; and both cone and 30-Hz flicker electroretinograms showed extinguished responses. His serum potassium level increased to 6.2 mmol/L (normal range 3.6–4.8 mmol/L) owing to hydronephrosis resulting from disseminated carcinoma. After performing an emergency surgery to treat this condition, the serum potassium level immediately decreased to a normal range. Eleven days after presentation, rod and standard/bright-flash electroretinography showed improvement in the implicit time of the rod b-waves and the a-waves. Unexpectedly, the responses recorded by cone and 30-Hz flicker electroretinography became normal. The symptoms and maculopathy disappeared, and his BCVA improved to 1.2. CONCLUSIONS: The abnormal electroretinographic findings might be associated with the transient increase in serum potassium level.
format Online
Article
Text
id pubmed-8494656
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-84946562021-10-15 Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report Kaizuka, Chihiro Hayashi, Takaaki Mizobuchi, Kei Kubota, Masaomi Ueno, Shinji Nakano, Tadashi Doc Ophthalmol Clinical Case Report PURPOSE: The purpose of this report was to describe the case of a 68-year-old male patient with stage IV colon cancer who exhibited electroretinographic abnormalities that are similar to those of KCNV2 retinopathy. METHODS: The patient presenting with photophobia, reduced visual acuity, and poor general conditions, the onset of which occurred ten days before presentation, was examined using fundoscopy, full-field electroretinography, blood tests, and abdominal computed tomography. RESULTS: The patient’s decimal best-corrected visual acuity (BCVA) was 0.4 in each eye. Fundoscopy showed bull's eye-like maculopathy in both eyes. Electroretinographic findings were similar to the characteristic findings of KCNV2 retinopathy: Rod electroretinogram showed delayed and preserved b-wave amplitudes; bright-flash electroretinogram showed double troughs of a-waves; b/a ratios shown by bright-flash electroretinogram were higher than those shown by standard-flash electroretinogram; and both cone and 30-Hz flicker electroretinograms showed extinguished responses. His serum potassium level increased to 6.2 mmol/L (normal range 3.6–4.8 mmol/L) owing to hydronephrosis resulting from disseminated carcinoma. After performing an emergency surgery to treat this condition, the serum potassium level immediately decreased to a normal range. Eleven days after presentation, rod and standard/bright-flash electroretinography showed improvement in the implicit time of the rod b-waves and the a-waves. Unexpectedly, the responses recorded by cone and 30-Hz flicker electroretinography became normal. The symptoms and maculopathy disappeared, and his BCVA improved to 1.2. CONCLUSIONS: The abnormal electroretinographic findings might be associated with the transient increase in serum potassium level. Springer Berlin Heidelberg 2021-03-18 2021 /pmc/articles/PMC8494656/ /pubmed/33738644 http://dx.doi.org/10.1007/s10633-021-09828-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Clinical Case Report
Kaizuka, Chihiro
Hayashi, Takaaki
Mizobuchi, Kei
Kubota, Masaomi
Ueno, Shinji
Nakano, Tadashi
Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report
title Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report
title_full Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report
title_fullStr Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report
title_full_unstemmed Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report
title_short Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report
title_sort transient electroretinographic abnormalities that mimic those of kcnv2 retinopathy: a case report
topic Clinical Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494656/
https://www.ncbi.nlm.nih.gov/pubmed/33738644
http://dx.doi.org/10.1007/s10633-021-09828-w
work_keys_str_mv AT kaizukachihiro transientelectroretinographicabnormalitiesthatmimicthoseofkcnv2retinopathyacasereport
AT hayashitakaaki transientelectroretinographicabnormalitiesthatmimicthoseofkcnv2retinopathyacasereport
AT mizobuchikei transientelectroretinographicabnormalitiesthatmimicthoseofkcnv2retinopathyacasereport
AT kubotamasaomi transientelectroretinographicabnormalitiesthatmimicthoseofkcnv2retinopathyacasereport
AT uenoshinji transientelectroretinographicabnormalitiesthatmimicthoseofkcnv2retinopathyacasereport
AT nakanotadashi transientelectroretinographicabnormalitiesthatmimicthoseofkcnv2retinopathyacasereport