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Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report
PURPOSE: The purpose of this report was to describe the case of a 68-year-old male patient with stage IV colon cancer who exhibited electroretinographic abnormalities that are similar to those of KCNV2 retinopathy. METHODS: The patient presenting with photophobia, reduced visual acuity, and poor gen...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494656/ https://www.ncbi.nlm.nih.gov/pubmed/33738644 http://dx.doi.org/10.1007/s10633-021-09828-w |
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author | Kaizuka, Chihiro Hayashi, Takaaki Mizobuchi, Kei Kubota, Masaomi Ueno, Shinji Nakano, Tadashi |
author_facet | Kaizuka, Chihiro Hayashi, Takaaki Mizobuchi, Kei Kubota, Masaomi Ueno, Shinji Nakano, Tadashi |
author_sort | Kaizuka, Chihiro |
collection | PubMed |
description | PURPOSE: The purpose of this report was to describe the case of a 68-year-old male patient with stage IV colon cancer who exhibited electroretinographic abnormalities that are similar to those of KCNV2 retinopathy. METHODS: The patient presenting with photophobia, reduced visual acuity, and poor general conditions, the onset of which occurred ten days before presentation, was examined using fundoscopy, full-field electroretinography, blood tests, and abdominal computed tomography. RESULTS: The patient’s decimal best-corrected visual acuity (BCVA) was 0.4 in each eye. Fundoscopy showed bull's eye-like maculopathy in both eyes. Electroretinographic findings were similar to the characteristic findings of KCNV2 retinopathy: Rod electroretinogram showed delayed and preserved b-wave amplitudes; bright-flash electroretinogram showed double troughs of a-waves; b/a ratios shown by bright-flash electroretinogram were higher than those shown by standard-flash electroretinogram; and both cone and 30-Hz flicker electroretinograms showed extinguished responses. His serum potassium level increased to 6.2 mmol/L (normal range 3.6–4.8 mmol/L) owing to hydronephrosis resulting from disseminated carcinoma. After performing an emergency surgery to treat this condition, the serum potassium level immediately decreased to a normal range. Eleven days after presentation, rod and standard/bright-flash electroretinography showed improvement in the implicit time of the rod b-waves and the a-waves. Unexpectedly, the responses recorded by cone and 30-Hz flicker electroretinography became normal. The symptoms and maculopathy disappeared, and his BCVA improved to 1.2. CONCLUSIONS: The abnormal electroretinographic findings might be associated with the transient increase in serum potassium level. |
format | Online Article Text |
id | pubmed-8494656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-84946562021-10-15 Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report Kaizuka, Chihiro Hayashi, Takaaki Mizobuchi, Kei Kubota, Masaomi Ueno, Shinji Nakano, Tadashi Doc Ophthalmol Clinical Case Report PURPOSE: The purpose of this report was to describe the case of a 68-year-old male patient with stage IV colon cancer who exhibited electroretinographic abnormalities that are similar to those of KCNV2 retinopathy. METHODS: The patient presenting with photophobia, reduced visual acuity, and poor general conditions, the onset of which occurred ten days before presentation, was examined using fundoscopy, full-field electroretinography, blood tests, and abdominal computed tomography. RESULTS: The patient’s decimal best-corrected visual acuity (BCVA) was 0.4 in each eye. Fundoscopy showed bull's eye-like maculopathy in both eyes. Electroretinographic findings were similar to the characteristic findings of KCNV2 retinopathy: Rod electroretinogram showed delayed and preserved b-wave amplitudes; bright-flash electroretinogram showed double troughs of a-waves; b/a ratios shown by bright-flash electroretinogram were higher than those shown by standard-flash electroretinogram; and both cone and 30-Hz flicker electroretinograms showed extinguished responses. His serum potassium level increased to 6.2 mmol/L (normal range 3.6–4.8 mmol/L) owing to hydronephrosis resulting from disseminated carcinoma. After performing an emergency surgery to treat this condition, the serum potassium level immediately decreased to a normal range. Eleven days after presentation, rod and standard/bright-flash electroretinography showed improvement in the implicit time of the rod b-waves and the a-waves. Unexpectedly, the responses recorded by cone and 30-Hz flicker electroretinography became normal. The symptoms and maculopathy disappeared, and his BCVA improved to 1.2. CONCLUSIONS: The abnormal electroretinographic findings might be associated with the transient increase in serum potassium level. Springer Berlin Heidelberg 2021-03-18 2021 /pmc/articles/PMC8494656/ /pubmed/33738644 http://dx.doi.org/10.1007/s10633-021-09828-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Clinical Case Report Kaizuka, Chihiro Hayashi, Takaaki Mizobuchi, Kei Kubota, Masaomi Ueno, Shinji Nakano, Tadashi Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report |
title | Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report |
title_full | Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report |
title_fullStr | Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report |
title_full_unstemmed | Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report |
title_short | Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report |
title_sort | transient electroretinographic abnormalities that mimic those of kcnv2 retinopathy: a case report |
topic | Clinical Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494656/ https://www.ncbi.nlm.nih.gov/pubmed/33738644 http://dx.doi.org/10.1007/s10633-021-09828-w |
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