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Langzeitergebnis nach akutem dialysepflichtigem Nierenversagen auf einer internistischen Intensivstation
BACKGROUND: Acute kidney injury (AKI) is a common and serious complication of acute life-threatening diseases. OBJECTIVES: The aim of this study was to investigate the effect of acute renal failure on mortality in intensive care patients, the need for renal replacement therapy at discharge, and the...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Medizin
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494662/ https://www.ncbi.nlm.nih.gov/pubmed/32821961 http://dx.doi.org/10.1007/s00063-020-00719-7 |
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author | Mizera, L. Dürr, M. M. Rath, D. Artunc, F. Gawaz, M. Riessen, R. |
author_facet | Mizera, L. Dürr, M. M. Rath, D. Artunc, F. Gawaz, M. Riessen, R. |
author_sort | Mizera, L. |
collection | PubMed |
description | BACKGROUND: Acute kidney injury (AKI) is a common and serious complication of acute life-threatening diseases. OBJECTIVES: The aim of this study was to investigate the effect of acute renal failure on mortality in intensive care patients, the need for renal replacement therapy at discharge, and the effect on long-term mortality. MATERIAL AND METHODS: Evaluation of 118 patient cases with dialysis-dependent acute renal failure between November 2016 and December 2017 admitted to a medical intensive care unit (ICU) at the University Hospital Tübingen, Germany. Dialysis at discharge and 1‑year mortality were defined as the primary endpoints. The secondary endpoint was need for continuous renal replacement after 18 months. RESULTS: In 118 patients, renal replacement modality by means of hemodialysis became necessary. A mortality rate of 45.8% (54/118) was found in patients requiring dialysis. Of the 64 surviving dialysis-dependent patients, 35.9% were still dependent on renal replacement therapy at the time of discharge. The 1‑year mortality rate was significantly higher in patients that still required dialysis at the time of discharge (p = 0.004). At 18-month follow-up, seven patients (10.9%) were still on renal replacement therapy. At this time, dialysis was significantly more frequent in patients with dialysis at the time of discharge than in dialysis-free patients (7.1% vs. 71.4%, p = 0.001). CONCLUSION: Severe episodes of AKI requiring renal replacement therapy in the setting of an ICU are associated with increased mortality 1 year after discharge and an increased requirement for renal replacement 18 months after discharge. |
format | Online Article Text |
id | pubmed-8494662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Medizin |
record_format | MEDLINE/PubMed |
spelling | pubmed-84946622021-10-19 Langzeitergebnis nach akutem dialysepflichtigem Nierenversagen auf einer internistischen Intensivstation Mizera, L. Dürr, M. M. Rath, D. Artunc, F. Gawaz, M. Riessen, R. Med Klin Intensivmed Notfmed Originalien BACKGROUND: Acute kidney injury (AKI) is a common and serious complication of acute life-threatening diseases. OBJECTIVES: The aim of this study was to investigate the effect of acute renal failure on mortality in intensive care patients, the need for renal replacement therapy at discharge, and the effect on long-term mortality. MATERIAL AND METHODS: Evaluation of 118 patient cases with dialysis-dependent acute renal failure between November 2016 and December 2017 admitted to a medical intensive care unit (ICU) at the University Hospital Tübingen, Germany. Dialysis at discharge and 1‑year mortality were defined as the primary endpoints. The secondary endpoint was need for continuous renal replacement after 18 months. RESULTS: In 118 patients, renal replacement modality by means of hemodialysis became necessary. A mortality rate of 45.8% (54/118) was found in patients requiring dialysis. Of the 64 surviving dialysis-dependent patients, 35.9% were still dependent on renal replacement therapy at the time of discharge. The 1‑year mortality rate was significantly higher in patients that still required dialysis at the time of discharge (p = 0.004). At 18-month follow-up, seven patients (10.9%) were still on renal replacement therapy. At this time, dialysis was significantly more frequent in patients with dialysis at the time of discharge than in dialysis-free patients (7.1% vs. 71.4%, p = 0.001). CONCLUSION: Severe episodes of AKI requiring renal replacement therapy in the setting of an ICU are associated with increased mortality 1 year after discharge and an increased requirement for renal replacement 18 months after discharge. Springer Medizin 2020-08-21 2021 /pmc/articles/PMC8494662/ /pubmed/32821961 http://dx.doi.org/10.1007/s00063-020-00719-7 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access Dieser Artikel wird unter der Creative Commons Namensnennung 4.0 International Lizenz veröffentlicht, welche die Nutzung, Vervielfältigung, Bearbeitung, Verbreitung und Wiedergabe in jeglichem Medium und Format erlaubt, sofern Sie den/die ursprünglichen Autor(en) und die Quelle ordnungsgemäß nennen, einen Link zur Creative Commons Lizenz beifügen und angeben, ob Änderungen vorgenommen wurden. Die in diesem Artikel enthaltenen Bilder und sonstiges Drittmaterial unterliegen ebenfalls der genannten Creative Commons Lizenz, sofern sich aus der Abbildungslegende nichts anderes ergibt. Sofern das betreffende Material nicht unter der genannten Creative Commons Lizenz steht und die betreffende Handlung nicht nach gesetzlichen Vorschriften erlaubt ist, ist für die oben aufgeführten Weiterverwendungen des Materials die Einwilligung des jeweiligen Rechteinhabers einzuholen. Weitere Details zur Lizenz entnehmen Sie bitte der Lizenzinformation auf http://creativecommons.org/licenses/by/4.0/deed.de (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Originalien Mizera, L. Dürr, M. M. Rath, D. Artunc, F. Gawaz, M. Riessen, R. Langzeitergebnis nach akutem dialysepflichtigem Nierenversagen auf einer internistischen Intensivstation |
title | Langzeitergebnis nach akutem dialysepflichtigem Nierenversagen auf einer internistischen Intensivstation |
title_full | Langzeitergebnis nach akutem dialysepflichtigem Nierenversagen auf einer internistischen Intensivstation |
title_fullStr | Langzeitergebnis nach akutem dialysepflichtigem Nierenversagen auf einer internistischen Intensivstation |
title_full_unstemmed | Langzeitergebnis nach akutem dialysepflichtigem Nierenversagen auf einer internistischen Intensivstation |
title_short | Langzeitergebnis nach akutem dialysepflichtigem Nierenversagen auf einer internistischen Intensivstation |
title_sort | langzeitergebnis nach akutem dialysepflichtigem nierenversagen auf einer internistischen intensivstation |
topic | Originalien |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494662/ https://www.ncbi.nlm.nih.gov/pubmed/32821961 http://dx.doi.org/10.1007/s00063-020-00719-7 |
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