Soluble Guanylate Cyclase Stimulators in Heart Failure

Heart failure has a high global burden of morbidity and mortality. Despite significant advances in medical management of heart failure, the prognosis remains poor. This justifies the search for newer therapeutic agents. Recently, soluble guanylate stimulators have demonstrated favorable results in c...

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Detalles Bibliográficos
Autores principales: Kansakar, Sajog, Guragain, Ashish, Verma, Deepak, Sharma, Prabhat, Dhungana, Bibek, Bhattarai, Bidit, Yadav, Sunil, Gautam, Nishant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Cardiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494752/
https://www.ncbi.nlm.nih.gov/pubmed/34659992
http://dx.doi.org/10.7759/cureus.17781
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author Kansakar, Sajog
Guragain, Ashish
Verma, Deepak
Sharma, Prabhat
Dhungana, Bibek
Bhattarai, Bidit
Yadav, Sunil
Gautam, Nishant
author_facet Kansakar, Sajog
Guragain, Ashish
Verma, Deepak
Sharma, Prabhat
Dhungana, Bibek
Bhattarai, Bidit
Yadav, Sunil
Gautam, Nishant
author_sort Kansakar, Sajog
collection PubMed
description Heart failure has a high global burden of morbidity and mortality. Despite significant advances in medical management of heart failure, the prognosis remains poor. This justifies the search for newer therapeutic agents. Recently, soluble guanylate stimulators have demonstrated favorable results in clinical trials. This article aims to summarize the guanylate cyclase signaling pathway, the role of soluble guanylate cyclase stimulators in heart failure, and data from recent clinical trials of these drugs. We concluded that soluble guanylate cyclase stimulators have significant benefits in reducing hospitalizations in patients with heart failure with reduced ejection fraction that are at high risk of cardiovascular events. There appears to be no benefit of these drugs in patients with heart failure with preserved ejection fraction.
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spelling pubmed-84947522021-10-14 Soluble Guanylate Cyclase Stimulators in Heart Failure Kansakar, Sajog Guragain, Ashish Verma, Deepak Sharma, Prabhat Dhungana, Bibek Bhattarai, Bidit Yadav, Sunil Gautam, Nishant Cureus Cardiology Heart failure has a high global burden of morbidity and mortality. Despite significant advances in medical management of heart failure, the prognosis remains poor. This justifies the search for newer therapeutic agents. Recently, soluble guanylate stimulators have demonstrated favorable results in clinical trials. This article aims to summarize the guanylate cyclase signaling pathway, the role of soluble guanylate cyclase stimulators in heart failure, and data from recent clinical trials of these drugs. We concluded that soluble guanylate cyclase stimulators have significant benefits in reducing hospitalizations in patients with heart failure with reduced ejection fraction that are at high risk of cardiovascular events. There appears to be no benefit of these drugs in patients with heart failure with preserved ejection fraction. Cureus 2021-09-06 /pmc/articles/PMC8494752/ /pubmed/34659992 http://dx.doi.org/10.7759/cureus.17781 Text en Copyright © 2021, Kansakar et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Kansakar, Sajog
Guragain, Ashish
Verma, Deepak
Sharma, Prabhat
Dhungana, Bibek
Bhattarai, Bidit
Yadav, Sunil
Gautam, Nishant
Soluble Guanylate Cyclase Stimulators in Heart Failure
title Soluble Guanylate Cyclase Stimulators in Heart Failure
title_full Soluble Guanylate Cyclase Stimulators in Heart Failure
title_fullStr Soluble Guanylate Cyclase Stimulators in Heart Failure
title_full_unstemmed Soluble Guanylate Cyclase Stimulators in Heart Failure
title_short Soluble Guanylate Cyclase Stimulators in Heart Failure
title_sort soluble guanylate cyclase stimulators in heart failure
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494752/
https://www.ncbi.nlm.nih.gov/pubmed/34659992
http://dx.doi.org/10.7759/cureus.17781
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