Identification of splice regulators of fibronectin-EIIIA and EIIIB by direct measurement of exon usage in a flow-cytometry based CRISPR screen

The extracellular matrix protein fibronectin (FN) is alternatively spliced in a variety of inflammatory conditions, resulting in increased inclusion of alternative exons EIIIA and EIIIB. Inclusion of these exons affects fibril formation, fibrosis, and inflammation. To define upstream regulators of a...

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Detalles Bibliográficos
Autores principales: Hensel, Jessica A., Heineman, Brent D., Kimble, Amy L., Jellison, Evan R., Reese, Bo, Murphy, Patrick A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494765/
https://www.ncbi.nlm.nih.gov/pubmed/34615942
http://dx.doi.org/10.1038/s41598-021-99079-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494765/
https://www.ncbi.nlm.nih.gov/pubmed/34615942
http://dx.doi.org/10.1038/s41598-021-99079-1

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