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Identification of splice regulators of fibronectin-EIIIA and EIIIB by direct measurement of exon usage in a flow-cytometry based CRISPR screen
The extracellular matrix protein fibronectin (FN) is alternatively spliced in a variety of inflammatory conditions, resulting in increased inclusion of alternative exons EIIIA and EIIIB. Inclusion of these exons affects fibril formation, fibrosis, and inflammation. To define upstream regulators of a...
Autores principales: | Hensel, Jessica A., Heineman, Brent D., Kimble, Amy L., Jellison, Evan R., Reese, Bo, Murphy, Patrick A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494765/ https://www.ncbi.nlm.nih.gov/pubmed/34615942 http://dx.doi.org/10.1038/s41598-021-99079-1 |
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