Cargando…

Efflux transporters in rat placenta and developing brain: transcriptomic and functional response to paracetamol

Adenosine triphosphate binding cassette (ABC) transporters transfer lipid-soluble molecules across cellular interfaces either directly or after enzymatic metabolism. RNAseq analysis identified transcripts for ABC transporters and enzymes in rat E19, P5 and adult brain and choroid plexus and E19 plac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koehn, L. M., Huang, Y., Habgood, M. D., Nie, S., Chiou, S. Y., Banati, R. B., Dziegielewska, K. M., Saunders, N. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494792/ https://www.ncbi.nlm.nih.gov/pubmed/34615937 http://dx.doi.org/10.1038/s41598-021-99139-6

Ejemplares similares

Effects of paracetamol (acetaminophen) on gene expression and permeability properties of the rat placenta and fetal brain
por: Koehn, Liam M., et al.
Publicado: (2020)

Brain barriers and functional interfaces with sequential appearance of ABC efflux transporters during human development
por: Møllgård, Kjeld, et al.
Publicado: (2017)

Transfer of rhodamine-123 into the brain and cerebrospinal fluid of fetal, neonatal and adult rats
por: Koehn, Liam M., et al.
Publicado: (2021)

Determinants of drug entry into the developing brain
por: Koehn, Liam, et al.
Publicado: (2019)

Developmental differences in the expression of ABC transporters at rat brain barrier interfaces following chronic exposure to diallyl sulfide
por: Koehn, Liam M., et al.
Publicado: (2019)

Entry of the antipsychotic drug, olanzapine, into the developing rat brain in mono- and combination therapies
por: Huang, Yifan, et al.
Publicado: (2023)

Lithium administered to pregnant, lactating and neonatal rats: entry into developing brain
por: Chiou, Shene Yi-Shiuan, et al.
Publicado: (2021)

Entry of antiepileptic drugs (valproate and lamotrigine) into the developing rat brain
por: Toll, Samuel J., et al.
Publicado: (2021)

Physiology and molecular biology of barrier mechanisms in the fetal and neonatal brain
por: Saunders, Norman R., et al.
Publicado: (2018)

The biological significance of brain barrier mechanisms: help or hindrance in drug delivery to the central nervous system?
por: Saunders, Norman R., et al.
Publicado: (2016)

Markers for blood-brain barrier integrity: how appropriate is Evans blue in the twenty-first century and what are the alternatives?
por: Saunders, Norman R., et al.
Publicado: (2015)

Effects of Neonatal Systemic Inflammation on Blood-Brain Barrier Permeability and Behaviour in Juvenile and Adult Rats
por: Stolp, H. B., et al.
Publicado: (2011)

Age dependent contribution of entry via the CSF to the overall brain entry of small and large hydrophilic markers
por: Qiu, Fiona, et al.
Publicado: (2022)

Developmental changes in the extent of drug binding to rat plasma proteins
por: Qiu, Fiona, et al.
Publicado: (2023)

Influx mechanisms in the embryonic and adult rat choroid plexus: a transcriptome study
por: Saunders, Norman R., et al.
Publicado: (2015)

ABC efflux transporters at blood-central nervous system barriers and their implications for treating spinal cord disorders
por: Koehn, Liam M.
Publicado: (2020)

Expression of ABC Efflux Transporters in Placenta from Women with Insulin-Managed Diabetes
por: Anger, Gregory J., et al.
Publicado: (2012)

Blocking of efflux transporters in rats improves translational validation of brain radioligands
por: Shalgunov, Vladimir, et al.
Publicado: (2020)

Pathological Changes in the White Matter after Spinal Contusion Injury in the Rat
por: Ek, C. Joakim, et al.
Publicado: (2012)

Mechanisms That Determine the Internal Environment of the Developing Brain: A Transcriptomic, Functional and Ultrastructural Approach
por: Liddelow, Shane A., et al.
Publicado: (2013)

Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury
por: Koehn, Liam M., et al.
Publicado: (2016)

The inner CSF–brain barrier: developmentally controlled access to the brain via intercellular junctions
por: Whish, Sophie, et al.
Publicado: (2015)

Correction: Mechanisms That Determine the Internal Environment of the Developing Brain: A Transcriptomic, Functional and Ultrastructural Approach
por: Liddelow, Shane A., et al.
Publicado: (2016)

Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates
por: Koenderink, Jan B., et al.
Publicado: (2020)

Efflux transporters in blood-brain interfaces of the developing brain
por: Strazielle, Nathalie, et al.
Publicado: (2015)

The rights and wrongs of blood-brain barrier permeability studies: a walk through 100 years of history
por: Saunders, Norman R., et al.
Publicado: (2014)

Barrier Mechanisms in the Developing Brain
por: Saunders, Norman R., et al.
Publicado: (2012)

Developmental changes in the transcriptome of the rat choroid plexus in relation to neuroprotection
por: Kratzer, Ingrid, et al.
Publicado: (2013)

Bioluminescent imaging of ABCG2 efflux activity at the blood-placenta barrier
por: Kumar, Jeyan S., et al.
Publicado: (2016)

Molecular Characterisation of Transport Mechanisms at the Developing Mouse Blood–CSF Interface: A Transcriptome Approach
por: Liddelow, Shane A., et al.
Publicado: (2012)

Paracetamol (Acetaminophen) and the Developing Brain
por: Bührer, Christoph, et al.
Publicado: (2021)

Spatio-Temporal Progression of Grey and White Matter Damage Following Contusion Injury in Rat Spinal Cord
por: Ek, C. Joakim, et al.
Publicado: (2010)

Correction: Molecular Characterisation of Transport Mechanisms at the Developing Mouse Blood–CSF Interface: A Transcriptome Approach
por: Liddelow, Shane A., et al.
Publicado: (2012)

Pharmacokinetics of Quinacrine Efflux from Mouse Brain via the P-glycoprotein Efflux Transporter
por: Ahn, Misol, et al.
Publicado: (2012)

Localisation of Lactate Transporters in Rat and Rabbit Placentae
por: Moore, Nigel P., et al.
Publicado: (2016)

Immune responses at brain barriers and implications for brain development and neurological function in later life
por: Stolp, Helen B., et al.
Publicado: (2013)

Effects of an Agaricus blazei Aqueous Extract Pretreatment on Paracetamol-Induced Brain and Liver Injury in Rats
por: Soares, Andréia A., et al.
Publicado: (2013)

A bipedal mammalian model for spinal cord injury research: The tammar wallaby
por: Saunders, Norman R., et al.
Publicado: (2017)

Paracetamol (Acetaminophen) and its Effect on the Developing Mouse Brain
por: Philippot, Gaëtan, et al.
Publicado: (2022)

The Transport of Oxygen in the Sheep's Placenta: The Diffusion Constant of the Placenta
por: Lamport, Harold
Publicado: (1954)

Cannot write session to /tmp/vufind_sessions/sess_bljadjgjbt707smhcmu1k0bqd4