Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing

Karyotype alterations have emerged as on-target complications from CRISPR-Cas9 genome editing. However, the events that lead to these karyotypic changes in embryos after Cas9-treatment remain unknown. Here, using imaging and single-cell genome sequencing of 8-cell stage embryos, we track both sponta...

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Detalles Bibliográficos
Autores principales: Papathanasiou, Stamatis, Markoulaki, Styliani, Blaine, Logan J., Leibowitz, Mitchell L., Zhang, Cheng-Zhong, Jaenisch, Rudolf, Pellman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494802/
https://www.ncbi.nlm.nih.gov/pubmed/34615869
http://dx.doi.org/10.1038/s41467-021-26097-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494802/
https://www.ncbi.nlm.nih.gov/pubmed/34615869
http://dx.doi.org/10.1038/s41467-021-26097-y

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